Stem Cells in the Cornea

被引:27
作者
Hertsenberg, Andrew J. [1 ]
Funderburgh, James L. [1 ]
机构
[1] Univ Pittsburgh, Dept Ophthalmol, Pittsburgh, PA 15260 USA
来源
MOLECULAR BIOLOGY OF EYE DISEASE | 2015年 / 134卷
关键词
IN-VITRO; PROGENITOR CELLS; N-CADHERIN; LIMBO-KERATOPLASTY; MESENCHYMAL CELLS; EPITHELIAL-CELLS; STROMAL TISSUE; EXPRESSION; MATRIX; GROWTH;
D O I
10.1016/bs.pmbts.2015.04.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The cornea is the tough, transparent tissue through which light first enters the eye and functions as a barrier to debris and infection as well as two-thirds of the refractive power of the eye. Corneal damage that is not promptly treated will often lead to scarring and vision impairment. Due to the limited options currently available to treat corneal scars, the identification and isolation of stem cells in the cornea has received much attention, as they may have potential for autologous, cell-based approaches to the treatment of damaged corneal tissue.
引用
收藏
页码:25 / 41
页数:17
相关论文
共 114 条
[2]   Corneal stromal and endothelial cell precursors [J].
Amano, Shiro ;
Yamagami, Satoru ;
Mimura, Tatsuya ;
Uchida, Saiko ;
Yokoo, Seiichi .
CORNEA, 2006, 25 (10) :S73-S77
[3]   Corneal reconstruction by stem cells and bioengineering [J].
Arjamaa, Olli .
CLINICAL OPHTHALMOLOGY, 2012, 6 :1407-1409
[4]   C/EBPδ regulates cell cycle and self-renewal of human limbal stem cells [J].
Barbaro, Vanessa ;
Testa, Anna ;
Di Iorio, Enzo ;
Mavilio, Fulvio ;
Pellegrini, Graziella ;
De Luca, Michele .
JOURNAL OF CELL BIOLOGY, 2007, 177 (06) :1037-1049
[5]   Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration [J].
Barker, Nick .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2014, 15 (01) :19-33
[6]   Human limbal biopsy-derived stromal stem cells prevent corneal scarring [J].
Basu, Sayan ;
Hertsenberg, Andrew J. ;
Funderburgh, Martha L. ;
Burrow, Michael K. ;
Mann, Mary M. ;
Du, Yiqin ;
Lathrop, Kira L. ;
Syed-Picard, Fatima N. ;
Adams, Sheila M. ;
Birk, David E. ;
Funderburgh, James L. .
SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (266)
[7]   Clinical outcomes of xeno-free allogeneic cultivated limbal epithelial transplantation for bilateral limbal stem cell deficiency [J].
Basu, Sayan ;
Fernandez, Mark M. ;
Das, Sujata ;
Gaddipati, Subhash ;
Vemuganti, Geeta K. ;
Sangwan, Virender S. .
BRITISH JOURNAL OF OPHTHALMOLOGY, 2012, 96 (12) :1504-1509
[8]   Mesenchymal Stem Cells in the Human Corneal Limbal Stroma [J].
Branch, Matthew James ;
Hashmani, Khurram ;
Dhillon, Permesh ;
Jones, D. Rhodri E. ;
Dua, Harminder Singh ;
Hopkinson, Andrew .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2012, 53 (09) :5109-5116
[9]   A dual-layer silk fibroin scaffold for reconstructing the human corneal limbus [J].
Bray, Laura J. ;
George, Karina A. ;
Hutmacher, Dietmar W. ;
Chirila, Traian V. ;
Harkin, Damien G. .
BIOMATERIALS, 2012, 33 (13) :3529-3538
[10]  
BUCK RC, 1985, INVEST OPHTH VIS SCI, V26, P1296