Induction of DNA damage by oxidised amino acids and proteins

被引：39

作者：

Luxford, C ^{[1
]}

Dean, RT ^{[1
]}

Davies, MJ ^{[1
]}

机构：

[1] Heart Res Inst, Sydney, NSW 2050, Australia

来源：

BIOGERONTOLOGY | 2002年 / 3卷 / 1-2期

基金：

澳大利亚研究理事会;

关键词：

DNA damage; DNA-protein cross-links; hydroperoxides; oxidation; protein damage; radicals; strand breaks;

D O I：

10.1023/A:1015228001561

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Exposure of amino acids, peptides and proteins to radicals in the presence of O-2 generates hydroperoxides in a dose-dependent manner. These hydroperoxides are stable in the absence of exogenous catalysts (e.g. heat, light, redox-active transition metal ions), but decompose rapidly in the presence of these agents to give a variety of radicals including alkoxyl (RO.), peroxyl (ROO.) and carbon-centred (R-.) species, These radicals are shown to react with DNA to give DNA-protein cross-links and single strand breaks.

引用

页码：95 / 102

页数：8

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