Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes

被引：44

作者：

Galczynska, Katarzyna ^{[1
]}

Drulis-Kawa, Zuzanna ^{[2
]}

Arabski, Michal ^{[1
]}

机构：

[1] Jan Kochanowski Univ, Inst Biol, Uniwersytecka 7, PL-25406 Kielce, Poland

[2] Univ Wroclaw, Inst Genet & Microbiol, Dept Pathogen Biol & Immunol, Przybyszewskiego 63-77, PL-51148 Wroclaw, Poland

来源：

MOLECULES | 2020年 / 25卷 / 15期

关键词：

cobalt; copper; ruthenium; imidazole; apoptosis; antitumor activity; CELL-DEATH; COPPER(II) COMPLEX; CANCER-CELLS; GALLIUM(III) COMPLEXES; DNA-BINDING; PLATINUM(II) COMPLEXES; PROTEASOME ACTIVITY; ANTICANCER ACTIVITY; CYTOTOXIC ACTIVITY; SIGNALING PATHWAY;

D O I：

10.3390/molecules25153492

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metal complexes are currently potential therapeutic compounds. The acquisition of resistance by cancer cells or the effective elimination of cancer-affected cells necessitates a constant search for chemical compounds with specific biological activities. One alternative option is the transition metal complexes having potential as antitumor agents. Here, we present the current knowledge about the application of transition metal complexes bearing nickel(II), cobalt(II), copper(II), ruthenium(III), and ruthenium(IV). The cytotoxic properties of the above complexes causing apoptosis, autophagy, DNA damage, and cell cycle inhibition are described in this review.

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页数：14

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