Amino-acid hydroselenites: synthesis and cytotoxicity

被引：10

作者：

Lukevics, E ^{[1
]}

Arsenyan, P ^{[1
]}

Rubina, K ^{[1
]}

Shestakova, I ^{[1
]}

Domracheva, I ^{[1
]}

Nesterova, A ^{[1
]}

Popelis, J ^{[1
]}

Pudova, O ^{[1
]}

机构：

[1] Latvian Inst Organ Synthesis, LV-1006 Riga, Latvia

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2002年 / 16卷 / 04期

关键词：

cell phenotype; cytotoxicity; hydroselenite; selenium;

D O I：

10.1002/aoc.277

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Amino acids, di- and tri-peptides readily react with selenic acid (H2SeO3, formed during solution of selenium(IV) oxide in water) to give the corresponding ammonium hydroselenites. Most selenites synthesized are very active (0.4-11 mug ml(-1)) against mouse hepatoma MG-22A and readily increase NO concentration in the cultural medium on the HT-1080 line (up to TG(100) = 1500%). The amino-acid hydroselenites studied influenced the cell phenotype. Copyright (C) 2002 John Wiley Sons, Ltd.

引用

页码：235 / 238

页数：4

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