Guideline for Primary Antifungal Prophylaxis for Pediatric Patients With Cancer or Hematopoietic Stem Cell Transplant Recipients

被引：66

作者：

Science, Michelle ^{[1
,2
]}

Robinson, Paula D. ^{[3
,4
]}

MacDonald, Tamara ^{[5
]}

Rassekh, Shahrad Rod ^{[6
]}

Dupuis, L. Lee ^{[7
,8
,9
]}

Sung, Lillian ^{[8
,9
]}

机构：

[1] Hosp Sick Children, Div Infect Dis, Toronto, ON M5G 1X8, Canada

[2] McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton Hlth Sci, Hamilton, ON, Canada

[3] Univ Alberta, Dept Pediat, Edmonton Clin Hlth Acad ECHA 3 590B, Council C17, Edmonton, AB, Canada

[4] Pediat Oncol Grp Ontario, Toronto, ON, Canada

[5] Dalhousie Univ, Dept Pharm, IWK Hlth Centrem, Halifax, NS, Canada

[6] BC Childrens Hosp, Div Pediat Hematol Oncol BMT, Vancouver, BC, Canada

[7] Univ Toronto, Hosp Sick Children, Leslie Dan Fac Pharm, Dept Pharm, Toronto, ON M5G 1X8, Canada

[8] Hosp Sick Children, Div Haematol Oncol, Toronto, ON M5G 1X8, Canada

[9] Hosp Sick Children, Program Child Hlth Evaluat Sci, Toronto, ON M5G 1X8, Canada

来源：

PEDIATRIC BLOOD & CANCER | 2014年 / 61卷 / 03期

关键词：

antifungal prophylaxis; bone marrow transplantation; hematopoietic stem cell transplantation; invasive fungal infection; pediatric cancer; INVASIVE FUNGAL-INFECTIONS; LIPOSOMAL AMPHOTERICIN-B; BONE-MARROW-TRANSPLANTATION; ACUTE MYELOID-LEUKEMIA; ITRACONAZOLE ORAL SOLUTION; ACUTE MYELOGENOUS LEUKEMIA; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND TRIAL; FLUCONAZOLE PROPHYLAXIS; NEUTROPENIC PATIENTS;

D O I：

10.1002/pbc.24847

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This guideline provides clinicians with evidence-based recommendations on the use of antifungal prophylaxis in children with cancer and undergoing hematopoietic stem cell transplantation (HSCT). Recommendations are divided into: (1) allogeneic HSCT (2) autologous HSCT (3) acute myeloid leukemia or myelodysplastic syndrome and (4) patients with malignancy and neutropenia for >7 days. A systematic review was conducted and evidence summaries compiled. The quality of evidence and strength of each recommendation was determined using GRADE. Implementation of these recommendations will require adaptation to local context. The contribution of this guideline in the prevention of invasive fungal infections requires prospective evaluation. Pediatr Blood Cancer 2014;61:393-400. (c) 2013 Wiley Periodicals, Inc.

引用

页码：393 / 400

页数：8

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