Functionalization of short multi-walled carbon nanotubes with creatinine and aromatic aldehydes via microwave and thermal methods and their influence on the MKN45 and MCF7 cancer cells

The chemical functionalization of carboxylated short multi-walled carbon nanotubes (Sh-MWCNT-COOH) by creatinine (Sh-MWCNT-amide) and later modification with aromatic aldehydes for producing 2-amino-5-arylidene-1-methyl-1H-imidazol-4(5H)-one (Sh-MWCNT-imidazols) via thermal and microwave methods have been investigated. All the products were characterized by Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscope, elemental analysis, thermogravimetric analysis, derivative thermogravimetric and cellular investigations. These functionalizations have been chosen due to the active sites of C=C and carbonyl groups in Sh-MWCNT-imidazols, which might be used as functional materials in the future. MU assay was used to examine the behavior of cell proliferation after 72 h of cell culture experiments. Cellular investigations were performed for two kinds of cells, human breast and gastric cancer cells. Cellular results showed high toxicity of modified Sh-MWCNTs on the gastric cancer cells compared to breast cells. (C) 2013 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.