Roles of follicle stimulating hormone and its receptor in human metabolic diseases and cancer

被引：4
作者：
Sun, Di [1 ,3 ]
Bai, Mingzhu [1 ,3 ]
Jiang, Yanyu [1 ,2 ]
Hu, Meiyan [1 ,2 ]
Wu, Sufang [3 ]
Zheng, Wenxin [4 ,5 ]
Zhang, Zhenbo [1 ,2 ,3 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Reprod Med Ctr, Dept Obstet & Gynecol, Shanghai 200080, Peoples R China
[2] Shanghai First Peoples Hosp, Dept Obstet & Gynecol, Baoshan Branch, Shanghai 201900, Peoples R China
[3] Shanghai Gen Hosp, Dept Obstet & Gynecol, Shanghai 200080, Peoples R China
[4] Univ Texas Southwestern Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA
[5] Univ Texas Southwestern Med Ctr Dallas, Dept Obstet & Gynecol, Dallas, TX 75390 USA
来源：
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2020年 / 12卷 / 07期
基金：
中国国家自然科学基金;
关键词：
Follicle stimulating hormone/receptor; lipogenesis; inflammation; insulin resistance; thermogenesis; skeletal metabolism; FATTY LIVER-DISEASE; PREVENTS BONE LOSS; ADIPOSE-TISSUE; SURFACE EPITHELIUM; WOMENS HEALTH; BETA-SUBUNIT; EXPRESSION; CELLS; TRANSITION; OBESITY;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Follicle stimulating hormone (FSH) and its receptor (FSHR) play an important role in human metabolic diseases and cancer. Evidence showed that FSHR is not only distributed in ovary and testis but also in other cells or organs such as osteoclast, adipocytes, liver, pituitary cancer and so forth. Moreover, FSH is associated with lipogen-esis, inflammation, insulin sensitivity, thermogenesis, skeletal metabolism, osteogenesis and ovarian cancer, all of which have been confirmed closely related to metabolic diseases or metabolic-related cancer. Therefore, FSH and FSHR may be potential therapeutic targets for metabolic diseases and metabolic-related cancer. Epidemiological researches revealed close relationship between FSH/FSHR and metabolic diseases or cancer. Experimental stud-ies elucidated the underlying mechanism both in vivo and in vitro. We reviewed the recent researches and present an integrated framework of FSH/FSHR and metabolic diseases and cancer, which provides potential targets for the treatments of metabolic diseases and cancer.
引用
收藏
页码：3116 / 3132
页数：17
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