Synthesis and evaluation of oligodeoxynucleotides containing 4'-C-substituted thymidines

被引：41
作者：
Wang, GY
Seifert, WE
机构：
[1] Research Department, ICN Pharmaceuticals, Inc., Costa Mesa, CA 92626
来源：
TETRAHEDRON LETTERS | 1996年 / 37卷 / 36期
关键词：
D O I：
10.1016/0040-4039(96)01432-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
4'-C-Hydroxymethylthymidine was converted to 4'-C-methoxymethylthymidine and 4'-C-aminomethylthymidine, which were incorporated into oligodeoxynucleotides by phosphoramidite chemistry. The modified oligonucleotides exhibit excellent hybridization and significant improvement in stability to snake venom phosphodiesterase. Copyright (C) 1996 Elsevier Science Ltd
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页码：6515 / 6518
页数：4
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