Current Understanding of the Role of the Brd4 Protein in the Papillomavirus Lifecycle

被引：36
|
作者：
McBride, Alison A. [1 ]
Jang, Moon Kyoo [1 ]
机构：
[1] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA
来源：
VIRUSES-BASEL | 2013年 / 5卷 / 06期
关键词：
Brd4; BET protein; HPV; papillomavirus; transcription; chromatin; replication; tethering; partitioning; bromodomain; BET BROMODOMAIN INHIBITION; RISK HUMAN-PAPILLOMAVIRUS; TYPE-16; DNA-REPLICATION; VIRAL E2 PROTEIN; BOVINE PAPILLOMAVIRUS; TRANSCRIPTIONAL ACTIVATION; E6; PROMOTER; P-TEFB; E2-MEDIATED REPRESSION; TRANSACTIVATION DOMAIN;
D O I：
10.3390/v5061374
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The Brd4 protein is an epigenetic reader that is central to regulation of cellular transcription and mitotic bookmarking. The transcription and replication proteins of many viruses interact with Brd4. We describe the multiple roles of Brd4 in the papillomavirus lifecycle.
引用
收藏
页码：1374 / 1394
页数：21
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