Serum fetuin-A levels are inversely associated with clinical severity in patients with primary knee osteoarthritis

被引：9

作者：

Xiao, Jie ^{[1
]}

Wang, Xiang-Rui ^{[1
]}

Hu, Kong-Zu ^{[2
]}

Li, Mao-Qiang ^{[3
]}

Chen, Jian-Wei ^{[4
]}

Ma, Tao ^{[4
]}

Li, Zhan-Chun ^{[4
]}

机构：

[1] Shanghai Jiao Tong Univ, Renji Hosp, Dept Anesthesiol, Sch Med, Shanghai 200127, Peoples R China

[2] Anhui Med Univ, Affiliated Hosp 1, Dept Orthopaed Surg, Hefei, Anhui, Peoples R China

[3] Hangzhou First Peoples Hosp, Dept Orthopaed Surg, Hangzhou, Zhejiang, Peoples R China

[4] Shanghai Jiao Tong Univ, Renji Hosp, Dept Orthopaed Surg, Sch Med, Shanghai 200127, Peoples R China

来源：

BIOMARKERS | 2013年 / 18卷 / 01期

关键词：

Osteoarthritis; fetuin-A; serum; biomarker; SYNOVIAL-FLUID; RADIOGRAPHIC SEVERITY; GLYCOPROTEIN/FETUIN-A; ARTHRITIS; OUTCOMES; PROTEIN; PLASMA; HIP;

D O I：

10.3109/1354750X.2012.730551

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The present study aimed to detect serum fetuin-A levels in knee osteoarthritis (OA) patients and to investigate their correlation with clinical severity. We enrolled 215 knee OA patients and 76 healthy controls. We measured serum fetuin-A levels by enzyme-linked immunosorbent assay and assessed the correlation between serum fetuin-A levels and Kellgren-Lawrence grades as well as Western Ontario and McMaster Universities Arthritis Index scores in OA patients. Our results demonstrated that serum fetuin-A levels were independently and negatively correlated with greater clinical severity in OA patients.

引用

页码：51 / 54

页数：4

共 19 条

[1] DEVELOPMENT OF CRITERIA FOR THE CLASSIFICATION AND REPORTING OF OSTEOARTHRITIS - CLASSIFICATION OF OSTEOARTHRITIS OF THE KNEE [J].

ALTMAN, R ;

ASCH, E ;

BLOCH, D ;

BOLE, G ;

BORENSTEIN, D ;

BRANDT, K ;

CHRISTY, W ;

COOKE, TD ;

GREENWALD, R ;

HOCHBERG, M ;

HOWELL, D ;

KAPLAN, D ;

KOOPMAN, W ;

LONGLEY, S ;

MANKIN, H ;

MCSHANE, DJ ;

MEDSGER, T ;

MEENAN, R ;

MIKKELSEN, W ;

MOSKOWITZ, R ;

MURPHY, W ;

ROTHSCHILD, B ;

SEGAL, M ;

SOKOLOFF, L ;

WOLFE, F .

ARTHRITIS AND RHEUMATISM, 1986, 29 (08) :1039-1049

[2]

BELLAMY N, 1988, J RHEUMATOL, V15, P1833

[3] Soluble receptor for advanced glycation end products (sRAGE) in plasma and synovial fluid is inversely associated with disease severity of knee osteoarthritis [J].

Chayanupatkul, Maneerat ;

Honsawek, Sittisak .

CLINICAL BIOCHEMISTRY, 2010, 43 (13-14) :1133-1137

[4] Association of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients [J].

Chen, Hung-Yuan ;

Chiu, Yen-Lin ;

Hsu, Shih-Ping ;

Pai, Mei-Fen ;

Lai, Chun-Fu ;

Peng, Yu-Sen ;

Kao, Tze-Wah ;

Hung, Kuan-Yu ;

Tsai, Tun-Jun ;

Wu, Kwan-Dun .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2009, 160 (05) :777-783

[5] Soluble P selectin in synovial fluid level is correlated with the radiographic severity of knee osteoarthritis [J].

Cheng, Tao ;

Li, Feng-Feng ;

Zhao, Song ;

Peng, Xiao-Chun ;

Zhang, Xian-Long .

CLINICA CHIMICA ACTA, 2010, 411 (19-20) :1529-1531

[6] Metabolic Syndrome and the Functional Outcomes of Hip and Knee Arthroplasty [J].

Gandhi, Rajiv ;

Razak, Fahad ;

Davey, J. Roderick ;

Mahomed, Nizar N. .

JOURNAL OF RHEUMATOLOGY, 2010, 37 (09) :1917-1922

[7] PURIFICATION AND CHARACTERIZATION OF THE 2 FORMS OF HUMAN-PLASMA ALPHA-2-HS-GLYCOPROTEIN [J].

GEJYO, F ;

SCHMID, K .

BIOCHIMICA ET BIOPHYSICA ACTA, 1981, 671 (01) :78-84

[8] Osteoarthritis year 2011 in review: biochemical markers of osteoarthritis: an overview of research and initiatives [J].

Henrotin, Y. .

OSTEOARTHRITIS AND CARTILAGE, 2012, 20 (03) :215-217

[9] Role of proinflammatory cytokines in the pathophysiology of osteoarthritis [J].

Kapoor, Mohit ;

Martel-Pelletier, Johanne ;

Lajeunesse, Daniel ;

Pelletier, Jean-Pierre ;

Fahmi, Hassan .

NATURE REVIEWS RHEUMATOLOGY, 2011, 7 (01) :33-42

[10] Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis [J].

Kraus, V. B. ;

Burnett, B. ;

Coindreau, J. ;

Cottrell, S. ;

Eyre, D. ;

Gendreau, M. ;

Gardiner, J. ;

Garnero, P. ;

Hardin, J. ;

Henrotin, Y. ;

Heinegard, D. ;

Ko, A. ;

Lohmander, L. S. ;

Matthews, G. ;

Menetski, J. ;

Moskowitz, R. ;

Persiani, S. ;

Poole, A. R. ;

Rousseau, J. -C. ;

Todman, M. .

OSTEOARTHRITIS AND CARTILAGE, 2011, 19 (05) :515-542

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