Shared-hole graph search with adaptive constraints for 3D optic nerve head optical coherence tomography image segmentation

Optic nerve head (ONH) is a crucial region for glaucoma detection and tracking based on spectral domain optical coherence tomography (SD-OCT) images. In this region, the existence of a "hole" structure makes retinal layer segmentation and analysis very challenging. To improve retinal layer segmentation, we propose a 3D method for ONH centered SD-OCT image segmentation, which is based on a modified graph search algorithm with a shared-hole and locally adaptive constraints. With the proposed method, both the optic disc boundary and nine retinal surfaces can be accurately segmented in SD-OCT images. An overall mean unsigned border positioning error of 7.27 +/- 5.40 mu m was achieved for layer segmentation, and a mean Dice coefficient of 0.925 +/- 0.03 was achieved for optic disc region detection. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement