Study on the Secondary Metabolites of the Endophytic Fungus Aspergillus terreus HQ100X-1 in Scutellaria formosana

被引：2
|
作者：
Huang, Dan [1 ,2 ]
Nong, Xuhua [1 ,2 ]
Yang, Jianni [1 ,2 ]
Li, Chen [1 ,2 ]
Han, Changri [3 ]
Chen, Guangying [1 ,2 ]
Song, Xiaoping [1 ,2 ]
Sun, Zhenfan [3 ]
Hui, Yang [1 ,2 ]
Chen, Wenhao [1 ,2 ]
机构：
[1] Hainan Normal Univ, Key Lab Trop Med Resource Chem, Minist Educ, Coll Chem & Chem Engn, Haikou 571158, Hainan, Peoples R China
[2] Hainan Normal Univ, Key Lab Trop Med Plant Chem Hainan Prov, Coll Chem & Chem Engn, Haikou 571158, Hainan, Peoples R China
[3] Hainan Vocat Univ Sci & Technol, Key Lab Med & Edible Plants Resources Hainan Prov, Haikou 571126, Hainan, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 42卷 / 09期
基金：
海南省自然科学基金; 中国国家自然科学基金;
关键词：
scutellaria formosana; Aspergillus terreus; antibacterial activity; NEOCLERODANE DITERPENOID ALKALOIDS; BARBATA; BUTENOLIDES; DERIVATIVES;
D O I：
10.6023/cjoc202202016
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two new compounds, terrustone (1) and asperteretone G (2) together with ten known compounds were isolated from Scutellaria formosana endophytic fungus Aspergillus terreus HQ100X-1, terrustone (1) is a trihydroxycyclopentanone with four consecutive chiral centers. Their structures were determined by 1D/2D NMR data along with electrostatic circular dichroism (ECD) calculation for configurational assignment. Compound rbrolide R (4) showed antibacterial activity against Staphylococcus aureus with minimum inhibitory concentration (MIC) value of 2.5 mu g/mL.
引用
收藏
页码：2961 / 2966
页数：6
相关论文
共 23 条
  • [1] Bioactive aromatic butenolides from a mangrove sediment originated fungal species, Aspergillus terreus SCAU011
    Bao, Jie
    Li, Xiu-Xiu
    Zhu, Kongkai
    He, Fei
    Wang, Yin-Yin
    Yu, Jin-Hai
    Zhang, Xiaoyong
    Zhang, Hua
    [J]. FITOTERAPIA, 2021, 150
  • [2] Natural and hemisynthetic neoclerodane diterpenoids from Scutellaria and their antifeedant activity
    Bruno, M
    Piozzi, F
    Rosselli, S
    [J]. NATURAL PRODUCT REPORTS, 2002, 19 (03) : 357 - 378
  • [3] Antimicrobial butyrolactone I derivatives from the ecuadorian soil fungus Aspergillus terreus thorn. Var terreus
    Cazar, ME
    Schmeda-Hirschmann, G
    Astudillo, L
    [J]. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2005, 21 (6-7): : 1067 - 1075
  • [4] Chen X., 2016, CHINESE J TROPICAL A, V36, P93
  • [5] Chen X., 2016, CHIN MED MAT, V39, P2240
  • [6] &ITNeo&IT-clerodane diterpenoids from the whole plants of &ITScutellaria&IT &ITformosana&IT
    Chen, Xin
    Chen, Wenhao
    Chen, Guangying
    Han, Changri
    He, Johnny J.
    Zhou, Xueming
    Yu, Zhangxin
    Dai, Chunyan
    Song, Xiaoping
    [J]. PHYTOCHEMISTRY, 2018, 145 : 1 - 9
  • [7] New neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities
    Dai, Sheng-Jun
    Liang, Dong-Dong
    Ren, Yan
    Liu, Ke
    Shen, Li
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, 56 (02) : 207 - 209
  • [8] neo-Clerodane diterpenoids from Scutellaria barbata with cytotoxic activities
    Dai, Sheng-Jun
    Tao, Jia-Yi
    Liu, Ke
    Jiang, Yong-Tao
    Shen, Li
    [J]. PHYTOCHEMISTRY, 2006, 67 (13) : 1326 - 1330
  • [9] Four new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities
    Dai, Sheng-Jun
    Chen, Meng
    Liu, Ke
    Jiang, Yong-Tao
    Shen, Li
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2006, 54 (06) : 869 - 872
  • [10] New neo-clerodane diterpenoids from Scutellaria barbata with cytotoxic activities
    Dai, Sheng-Jun
    Qu, Gui-Wu
    Yu, Qun-Ying
    Zhang, De-Wu
    Li, Gui-Sheng
    [J]. FITOTERAPIA, 2010, 81 (07) : 737 - 741
123