Study on the Secondary Metabolites of the Endophytic Fungus Aspergillus terreus HQ100X-1 in Scutellaria formosana

被引：2
|
作者：
Huang, Dan [1 ,2 ]
Nong, Xuhua [1 ,2 ]
Yang, Jianni [1 ,2 ]
Li, Chen [1 ,2 ]
Han, Changri [3 ]
Chen, Guangying [1 ,2 ]
Song, Xiaoping [1 ,2 ]
Sun, Zhenfan [3 ]
Hui, Yang [1 ,2 ]
Chen, Wenhao [1 ,2 ]
机构：
[1] Hainan Normal Univ, Key Lab Trop Med Resource Chem, Minist Educ, Coll Chem & Chem Engn, Haikou 571158, Hainan, Peoples R China
[2] Hainan Normal Univ, Key Lab Trop Med Plant Chem Hainan Prov, Coll Chem & Chem Engn, Haikou 571158, Hainan, Peoples R China
[3] Hainan Vocat Univ Sci & Technol, Key Lab Med & Edible Plants Resources Hainan Prov, Haikou 571126, Hainan, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 42卷 / 09期
基金：
中国国家自然科学基金; 海南省自然科学基金;
关键词：
scutellaria formosana; Aspergillus terreus; antibacterial activity; NEOCLERODANE DITERPENOID ALKALOIDS; BARBATA; BUTENOLIDES; DERIVATIVES;
D O I：
10.6023/cjoc202202016
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two new compounds, terrustone (1) and asperteretone G (2) together with ten known compounds were isolated from Scutellaria formosana endophytic fungus Aspergillus terreus HQ100X-1, terrustone (1) is a trihydroxycyclopentanone with four consecutive chiral centers. Their structures were determined by 1D/2D NMR data along with electrostatic circular dichroism (ECD) calculation for configurational assignment. Compound rbrolide R (4) showed antibacterial activity against Staphylococcus aureus with minimum inhibitory concentration (MIC) value of 2.5 mu g/mL.
引用
收藏
页码：2961 / 2966
页数：6
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