TRP channels: diagnostic markers and therapeutic targets for breast cancer?

被引：74
作者：
Ouadid-Ahidouch, Halima [1 ]
Dhennin-Duthille, Isabelle [1 ]
Gautier, Mathieu [1 ]
Sevestre, Henri [1 ,2 ]
Ahidouch, Ahmed [1 ,3 ]
机构：
[1] Univ Picardie Jules Verne, UFR Sci, Lab Cell & Mol Physiol EA4667, SFR CAP SANTE FED 4231, Amiens, France
[2] Univ Picardie Jules Verne, Amiens Hosp, Dept Pathol & Tumorotheque Picardie, Amiens, France
[3] Ibn Zohr Univ, Fac Sci, Dept Biol, Agadir, Morocco
来源：
TRENDS IN MOLECULAR MEDICINE | 2013年 / 19卷 / 02期
关键词：
breast cancer; TRP; proliferation; migration; estrogen receptors; cancer biomarkers; CALCIUM-TRANSPORT; ION-CHANNEL; PROSTATE-CANCER; K+ CHANNELS; EXPRESSION; CELLS; PROLIFERATION; MIGRATION; TISSUES; CATION;
D O I：
10.1016/j.molmed.2012.11.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Breast cancer is the most frequently occurring cancer in women and has the highest rate of mortality. Ion channels such as the transient receptor potential (TRP) channels could play a critical role in the development and progression of cancer. Although these channels are frequently and abundantly expressed in many tumors, their expression, activity, and roles in the context of breast cancer remain poorly understood. This review summarizes our current knowledge regarding TRP channels expressed in human breast tissue, primary human breast epithelial cells, and cell lines, the functional role of TRP channels during breast cancer cell growth and migration, as well as their relationship with clinical and pathological features.
引用
收藏
页码：117 / 124
页数：8
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