Endoplasmic Reticulum Stress in Chronic Obstructive Pulmonary Disease: Mechanisms and Future Perspectives

被引：18

作者：

Yu, Yue ^{[1
]}

Yang, Ailin ^{[1
]}

Yu, Ganggang ^{[1
]}

Wang, Haoyan ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Friendship Hosp, Dept Resp Med, Beijing 100050, Peoples R China

来源：

BIOMOLECULES | 2022年 / 12卷 / 11期

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

endoplasmic reticulum stress; chronic obstructive pulmonary disease; inflammation; apoptosis; autophagy; therapeutic; UNFOLDED PROTEIN RESPONSE; XBP1; MESSENGER-RNA; FACTOR-KAPPA-B; CIGARETTE-SMOKE; ER STRESS; HOMOLOGOUS PROTEIN; INDUCED AUTOPHAGY; INDEPENDENT ACTIVATION; CELLULAR SENESCENCE; ENDOTHELIAL-CELLS;

D O I：

10.3390/biom12111637

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The endoplasmic reticulum (ER) is an integral organelle for maintaining protein homeostasis. Multiple factors can disrupt protein folding in the lumen of the ER, triggering ER stress and activating the unfolded protein response (UPR), which interrelates with various damage mechanisms, such as inflammation, apoptosis, and autophagy. Numerous studies have linked ER stress and UPR to the progression of chronic obstructive pulmonary disease (COPD). This review focuses on the mechanisms of other cellular processes triggered by UPR and summarizes drug intervention strategies targeting the UPR pathway in COPD to explore new therapeutic approaches and preventive measures for COPD.

引用

页数：20

共 168 条

[11] 4-PBA rescues hyperoxaluria induced nephrolithiasis by modulating urinary glycoproteins: Cross talk between endoplasmic reticulum, calcium homeostasis and mitochondria [J].

Bhardwaj, Rishi ;

Bhardwaj, Ankita ;

Dhawan, Devinder K. ;

Tandon, Chanderdeep ;

Kaur, Tanzeer .

LIFE SCIENCES, 2022, 305

[12] The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling [J].

Bhattarai, Kashi Raj ;

Riaz, Thoufiqul Alam ;

Kim, Hyung-Ryong ;

Chae, Han-Jung .

EXPERIMENTAL AND MOLECULAR MEDICINE, 2021, 53 (02) :151-167

[13] Endoplasmic Reticulum (ER) Stress Response Failure in Diseases [J].

Bhattarai, Kashi Raj ;

Chaudhary, Manoj ;

Kim, Hyung-Ryong ;

Chae, Han-Jung .

TRENDS IN CELL BIOLOGY, 2020, 30 (09) :672-675

[14] Autoreactivity to Glucose Regulated Protein 78 Links Emphysema and Osteoporosis in Smokers [J].

Bon, Jessica ;

Kahloon, Rehan ;

Zhang, Yingze ;

Xue, Jianmin ;

Fuhrman, Carl R. ;

Tan, Jiangning ;

Burger, Mathew ;

Kass, Daniel J. ;

Csizmadia, Eva ;

Otterbein, Leo ;

Chandra, Divay ;

Bhargava, Arpit ;

Pilewski, Joseph M. ;

Roodman, G. David ;

Sciurba, Frank C. ;

Duncan, Steven R. .

PLOS ONE, 2014, 9 (09)

[15] PERK mediates cell-cycle exit during the mammalian unfolded protein response [J].

Brewer, JW ;

Diehl, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (23) :12625-12630

[16] Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3-and Caspase-2-Driven Mitochondrial Damage [J].

Bronner, Denise N. ;

Abuaita, Basel H. ;

Chen, Xiaoyun ;

Fitzgerald, Katherine A. ;

Nunez, Gabriel ;

He, Yongqun ;

Yin, Xiao-Ming ;

O'Riordan, Mary X. D. .

IMMUNITY, 2015, 43 (03) :451-462

[17] IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA [J].

Calfon, M ;

Zeng, HQ ;

Urano, F ;

Till, JH ;

Hubbard, SR ;

Harding, HP ;

Clark, SG ;

Ron, D .

NATURE, 2002, 415 (6867) :92-96

[18] Grape seed proanthocyanidin extract ameliorates cisplatin-induced testicular apoptosis via PI3K/Akt/mTOR and endoplasmic reticulum stress pathways in rats [J].

Chang, Xuhong ;

Tian, Minmin ;

Zhang, Qiong ;

Liu, Fangfang ;

Gao, Jinxia ;

Li, Sheng ;

Liu, Han ;

Hou, Xiangbo ;

Li, Lei ;

Li, Chengyun ;

Sun, Yingbiao .

JOURNAL OF FOOD BIOCHEMISTRY, 2021, 45 (08)

[19] Chlamydia psittaci Induces Autophagy in Human Bronchial Epithelial Cells via PERK and IRE1α, but Not ATF6 Pathway [J].

Chen, Li ;

Huang, Qiaoling ;

Bai, Qinqin ;

Tong, Ting ;

Zhou, You ;

Li, Zhongyu ;

Xiao, Cui ;

Chen, Lili .

INFECTION AND IMMUNITY, 2022, 90 (05)

[20] ORMDL3 regulates cigarette smoke-induced endoplasmic reticulum stress in airway smooth muscle cells [J].

Chen, Rui ;

Michaeloudes, Charalambos ;

Liang, Yingmin ;

Bhavsar, Pankaj K. ;

Chung, Kian Fan ;

Ip, Mary S. M. ;

Mak, Judith C. W. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022, 149 (04) :1445-+

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