Square-wave voltammetric determination of bezafibrate in pharmaceutical formulations using a cathodically pretreated boron-doped diamond electrode

被引：39

作者：

Ardila, Jorge Armando ^{[1
]}

Sartori, Elen Romao ^{[1
,2
]}

Rocha-Filho, Romeu C. ^{[1
]}

Fatibello-Filho, Orlando ^{[1
]}

机构：

[1] Univ Fed Sao Carlos, Dept Quim, BR-13560970 Sao Carlos, SP, Brazil

[2] Univ Estadual Londrina, Dept Quim, BR-86051990 Londrina, PR, Brazil

来源：

TALANTA | 2013年 / 103卷

基金：

巴西圣保罗研究基金会;

关键词：

Bezafibrate electroanalytical determination; BDD electrode; Cathodic pretreatment; Square-wave voltammeny; PULSE AMPEROMETRIC DETECTION; ELECTROCHEMICAL DETERMINATION; SYNTHETIC COLORANTS; ASCORBIC-ACID; CAFFEINE; BEHAVIOR; SYSTEM;

D O I：

10.1016/j.talanta.2012.10.033

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The determination of bezafibrate (BZF) using square-wave voltammetry (SWV) and a cathodically pretreated boron-doped diamond electrode is proposed. Cyclic voltammetry results showed one irreversible oxidation peak for BZF at 1.20 V (vs. Ag/AgCl (3.0 mol L-1 KCl)) in a 0.04 mol L-1 Britton-Robinson (BR) buffer solution (pH 2.0). Under optimized SWV conditions, a linear analytical curve is obtained for the BZF concentration range 0.10-9.1 mu mol L-1 in the BR buffer solution (pH 2.0), with a detection limit of 0.098 mu mol L-1. The obtained recoveries range from 93.4 to 108%. The proposed novel method was successfully applied in the determination of the BZF content in several pharmaceutical formulations (tablets) and the results are in close agreement (at a 95% confidence level) with those obtained using a comparative spectrophotometric method. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：201 / 206

页数：6

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