Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases

被引:216
作者
Li, Sha [1 ]
Hong, Ming [1 ]
Tan, Hor-Yue [1 ]
Wang, Ning [1 ]
Feng, Yibin [1 ]
机构
[1] Univ Hong Kong, Li Ka Shing Fac Med, Sch Chinese Med, Pokfulam, Hong Kong, Peoples R China
关键词
REGULATORY T-CELLS; HIGH-FAT DIET; CYCLOPHOSPHAMIDE-INDUCED HEPATOTOXICITY; TRANSGENIC MOUSE MODEL; SUPPRESSOR-CELLS; INSULIN-RESISTANCE; REACTIVE OXYGEN; KUPFFER CELLS; HEPATIC INFLAMMATION; LIPOIC ACID;
D O I
10.1155/2016/4234061
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The crucial roles of oxidative stress and inflammation in the development of hepatic diseases have been unraveled and emphasized for decades. From steatosis to fibrosis, cirrhosis and liver cancer, hepatic oxidative stress, and inflammation are sustained and participated in this pathological progressive process. Notably, increasing evidences showed that oxidative stress and inflammation are tightly related, which are regarded as essential partners that present simultaneously and interact with each other in various pathological conditions, creating a vicious cycle to aggravate the hepatic diseases. Clarifying the interaction of oxidative stress and inflammation is of great importance to provide new directions and targets for developing therapeutic intervention. Herein, this review is concerned with the regulation and interdependence of oxidative stress and inflammation in a variety of liver diseases. In addition to classical mediators and signaling, particular emphasis is placed upon immune suppression, a potential linkage of oxidative stress and inflammation, to provide new inspiration for the treatment of liver diseases. Furthermore, since antioxidation and anti-inflammation have been extensively attempted as the strategies for treatment of liver diseases, the application of herbal medicines and their derived compounds that protect liver from injury via regulating oxidative stress and inflammation collectively were reviewed and discussed.
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页数:21
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