Transforming growth factor-β and multidrug resistance in chronic lymphocytic leukemia

被引：14
作者：
Friedenberg, WR
Salzman, SA
Phan, SM
Burmester, JK
机构：
[1] Marshfield Clin Fdn Med Res & Educ, Marshfield, WI 54449 USA
[2] Marshfield Clin, Dept Hematol Oncol, Marshfield, WI USA
来源：
MEDICAL ONCOLOGY | 1999年 / 16卷 / 02期
关键词：
receptor; crosslinking; growth factors; plasma levels; blood disease;
D O I：
10.1007/BF02785844
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Patients with chronic lymphocytic leukemia (CLL) frequently respond to initial treatment, but then become resistant to chemotherapy. Studies have shown one important cause of chemotherapeutic resistance to be multidrug resistance (MDR). To investigate the potential role of MDR and transforming growth factor-beta (TFG-beta), a potent growth inhibitor of B lymphocytes, in the development of chemotherapeutic resistance in CLL, we evaluated 22 CLL patients far loss or mutation of TGF-beta receptors (TPR), plasma TGF-beta 1 levels, and expression of MDR1 mRNA. Receptor crosslinking and immunoprecipitation experiments did not demonstrate loss of T beta Rs in any patients studied. No relationship between plasma TGF-beta 1 levels and expression of MDR1 mRNA was seen. Correlation of plasma TGF-beta 1 levels to disease stage revealed a consistent, decline in plasma TGF-beta 1 levels with advancing disease stage (P = 0.031).
引用
收藏
页码：110 / 118
页数：9
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