Fc gamma receptor IIIa polymorphism is not associated with susceptibility to systemic lupus erythematosus in Brazilian patients

被引：2

作者：

Grecco, Marcelle ^{[1
]}

dos Santos, Viviane Cardoso ^{[1
]}

Costa Pereira, Kaline Medeiros ^{[1
]}

Coelho Andrade, Luis Eduardo ^{[1
]}

da Silva, Neusa Pereira ^{[1
]}

机构：

[1] Univ Fed Sao Paulo UNIFESP, Dept Med, Disciplina Reumatol, Sao Paulo, SP, Brazil

来源：

REVISTA BRASILEIRA DE REUMATOLOGIA | 2016年 / 56卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

Systemic lupus erythematosus; Fc gamma receptor IIIa; Single nucleotide polymorphism; Gene polymorphism; Immunogenetics; COPY NUMBER VARIATION; KOREAN PATIENTS; DISEASE; RIIIA; GENE; AUTOIMMUNITY; PREDISPOSES; NEPHRITIS; FCGR2B; ALLELE;

D O I：

10.1016/j.rbre.2016.07.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We evaluated the possible association between FCGR3AV/F (158) polymorphism and SLE susceptibility and clinical phenotype in 305 sequentially retrieved SLE patients and 300 healthy controls from the southeastern part of Brazil by allele-specific polymerise chain reaction. Our results showed no association between FCGR3A 158V/F alleles and susceptibility to SLE in this series of patients albeit the heterozygous genotype was strongly associated with the disease. (C) 2016 Published by Elsevier Editora Ltda.

引用

页码：515 / 520

页数：6

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