Immunology of fungal infections: lessons learned from animal models

被引：7

作者：

Steele, Chad ^{[3
]}

Wormley, Floyd L., Jr. ^{[1
,2
]}

机构：

[1] Univ Texas San Antonio, Dept Biol, San Antonio, TX 78249 USA

[2] Univ Texas San Antonio, S Texas Ctr Emerging Infect Dis, San Antonio, TX 78249 USA

[3] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2012年 / 15卷 / 04期

关键词：

CLASSICAL MACROPHAGE ACTIVATION; BETA-GLUCAN RECOGNITION; HOST-DEFENSE; CANDIDA-ALBICANS; CRYPTOCOCCUS-NEOFORMANS; TH17; CELLS; PNEUMOCYSTIS-CARINII; PULMONARY INFECTION; NLRP3; INFLAMMASOME; ADAPTIVE IMMUNITY;

D O I：

10.1016/j.mib.2012.05.017

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The continuing AIDS epidemic coupled with increased usage of immunosuppressive drugs to prevent organ rejection or treat autoimmune diseases has resulted in an increase in individuals at risk for acquiring fungal diseases. These concems highlight the need to elucidate mechanisms of inducing protective immune responses against fungal pathogens. Consequently, several experimental models of human mycoses have been developed to study these diseases. The availability of transgenic animal models allows for in-depth analysis of specific components, receptors, and signaling pathways that elicit protection against fungal diseases. This review focuses on recent advances in our understanding of immune responses to fungal infections gained using animal models.

引用

页码：413 / 419

页数：7

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