Fcγ-receptor IIA genotype and invasive pneumococcal infection

被引：27

作者：

Moens, L

Van Hoeyveld, E

Verhaegen, J

De Boeck, K

Peetermans, WE

Bossuyt, X

机构：

[1] Univ Hosp Louvain, Dept Lab Med, B-3000 Louvain, Belgium

[2] Univ Hosp Louvain, Dept Pediat, B-3000 Louvain, Belgium

[3] Univ Hosp Louvain, Dept Internal Med, B-3000 Louvain, Belgium

来源：

CLINICAL IMMUNOLOGY | 2006年 / 118卷 / 01期

关键词：

Fc gamma-RIIA polymorphism; Streptococcus pneumoniae; invasive pneumococcal infection;

D O I：

10.1016/j.clim.2005.08.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Streptococcus pneumoniae is a major cause of pneumonia, bacteraemia, meningitis, and acute otitis media, especially in young children, immunocompromised patients, and elderly. Fc gamma-IIA receptor plays a crucial role in the phagocytosis of IgG2-opsonized bacteria since it is the sole receptor able to interact with IgG2 antibodies. Fc gamma-RIIA exhibits allelic polymorphisms with different capacities for binding IgG2 and phagocytosis. In a prospective study, we genotyped Fc gamma-RIIA in 55 Caucasian patients suffering from invasive pneumococcal disease and in 100 Caucasian controls. In contrast to previous reports, we found no association between Fc gamma-RIIA genotype and invasive pneumococcal disease. (c) 2005 Elsevier Inc. All rights reserved.

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页码：20 / 23

页数：4

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