C-erb-B2 (Her2/neu) Expression Rate And its Association with Clinicopathologic Parameters in Gastric Cancer

被引:0
|
作者
Yildirim, Sukru [1 ]
Dandin, Ozgur [2 ]
Durmus, Muzaffer [3 ]
Karapinar, Ugur [4 ]
Aslan, Murat [5 ]
Gokce, Mehmet [6 ]
Sahin, Fadime [6 ]
机构
[1] Bursa Mil Hosp, Dept Pathol, Bursa, Turkey
[2] Bursa Mil Hosp, Dept Gen Surg, Bursa, Turkey
[3] Bursa Mil Hosp, Dept Plast & Reconstruct Surg, Bursa, Turkey
[4] Bursa Mil Hosp, Dept Ear Nose Throat, Bursa, Turkey
[5] Bursa Mil Hosp, Dept Oncol, Bursa, Turkey
[6] Patomer Pathol Lab, Bursa, Turkey
来源
UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI | 2012年 / 22卷 / 03期
关键词
C-erb-B2; Gastric adenocarcinoma; Immunohistochemistry; Trastuzumab; IN-SITU HYBRIDIZATION; C-ERBB-2; GENE; AMPLIFICATION; CARCINOMA; PROGNOSIS; IMMUNOHISTOCHEMISTRY; OVEREXPRESSION; ADENOCARCINOMA; GROWTH;
D O I
10.4999/uhod.12044
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We aimed to investigate the frequency of c-erb-B2 expression rate and its association with clinicopathological parameters in our gastric carcinoma series to make a contribution to emerging data on this oncogene. One hundred thirty-nine gastric adenocarcinoma patients underwent total gastrectomy between years 2006 and 2011 were selected to the study. C-erb-B2 expressions were determined by using immunohistochemical and/or chromogenic in situ hybridisation methods in tumor tissues. A total of 16 (11.5%) gastric adenocarcinoma cases were found positive for c-erb-B2 expression. Out of 16 positive cases, 13 had intestinal type adenocarcinomas. C-erb-B2 overexpression was significantly associated with histologic subtype (p= 0.001), and histologic tumor grade (p= 0.001). The frequency of overexpression in intestinal subtype (21.7%) was comparable with the known rates of overexpression in breast cancer. This results indicate that C-erb-B2 expression may identify a subgroup in gastric carcinoma cases which may benefit from targeted treatment modalities among Turkish population.
引用
收藏
页码:156 / 162
页数:7
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