New one-pot approach to regio-synthesis of substituted 2-aminothiazoles from the corresponding keto-aziridines

被引：17
|
作者：
Samimi, Heshmat A. [1 ]
Mohammadi, Somaye [1 ]
机构：
[1] Univ Shahrekord, Fac Sci, Dept Chem, Shahrekord, Iran
来源：
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY | 2014年 / 11卷 / 01期
关键词：
Aziridine; 2-Aminothiazoles; Ring expansion; RuCl3; EFFICIENT SYNTHESIS; RECEPTOR ANTAGONISTS; DERIVATIVES; AGENTS; INHIBITORS; CONVENIENT; DISCOVERY; THIAZOLE; ANALOGS; SYSTEM;
D O I：
10.1007/s13738-013-0276-7
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Ring expansion of keto-aziridines to the corresponding 2-aminothiazoles (54-67 %) using ammonium thiocyanate in the presence of RuCl3 under refluxing acetonitrile is described. A plausible mechanism for the synthesis of substituted 2-aminothiazoles has been proposed.
引用
收藏
页码：69 / 73
页数：5
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