Steroidal glycosides from the bulbs of Bessera elegans and their cytotoxic activities

被引：16

作者：

Matsuo, Yukiko ^{[1
]}

Akagi, Nana ^{[1
]}

Hashimoto, Chisato ^{[1
]}

Tachikawa, Fumito ^{[1
]}

Mimaki, Yoshihiro ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Hachioji, Tokyo 1920392, Japan

来源：

PHYTOCHEMISTRY | 2013年 / 96卷

关键词：

Bessera elegans; Liliaceae; Steroidal glycoside; A549; cells; HL-60; Cytotoxicity; Apoptosis; ORNITHOGALUM-SAUNDERSIAE; CHOLESTANE GLYCOSIDES; DIGITALIS-CILIATA; SAPONINS; RHIZOMES;

D O I：

10.1016/j.phytochem.2013.09.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Examination of the bulbs of Bessera elegans (Liliaceae) led to isolation of nine new and five known steroidal glycosides. The structures of the nine compounds were determined based on the results of spectroscopic analysis, including two-dimensional NMR, and hydrolysis followed by chromatographic and spectroscopic analysis. The isolated compounds and derivatives were evaluated for cytotoxicity against HL-60 human promyelocytic leukemia cells, A549 human lung adenocarcinoma cells, and TIG-3 normal human diploid fibroblasts. One compound, the pseudo-furostanol glycoside, induced apoptosis in HL-60 and A549 cells in a time-dependent manner and cell-cycle arrest at the G0/G1 phase in A549 cells. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：244 / 256

页数：13

共 16 条

[1] Structure-activity relationships for Saponins from Allium hirtifolium and Allium elburzense and their antispasmodic activity [J].

Barile, E ;

Capasso, R ;

Izzo, AA ;

Lanzotti, V ;

Sajjadi, SE ;

Zolfaghari, B .

PLANTA MEDICA, 2005, 71 (11) :1010-1018

[2] Steroidal saponins from Tribulus terrestris [J].

Cai, LF ;

Wu, YJ ;

Zhang, JG ;

Pei, FK ;

Xu, YJ ;

Xie, SX ;

Xu, DM .

PLANTA MEDICA, 2001, 67 (02) :196-198

[3] Steroidal glycosides from Digitalis ciliata leaves [J].

Gvazava, L. N. ;

Kikoladze, V. S. .

CHEMISTRY OF NATURAL COMPOUNDS, 2006, 42 (05) :562-566

[4] FUROSTANE-TYPE STEROIDAL SAPONIN FROM Digitalis ciliata [J].

Gvazava, L. N. ;

Kikoladze, V. S. .

CHEMISTRY OF NATURAL COMPOUNDS, 2010, 46 (02) :246-249

[5]

Ikeda T, 2000, CHEM PHARM BULL, V48, P1062

[6] ACYLATED CHOLESTANE GLYCOSIDES FROM THE BULBS OF ORNITHOGALUM-SAUNDERSIAE [J].

KUBO, S ;

MIMAKI, Y ;

TERAO, M ;

SASHIDA, Y ;

NIKAIDO, T ;

OHMOTO, T .

PHYTOCHEMISTRY, 1992, 31 (11) :3969-3973

[7] Galtonioside A, a novel cytotoxic cholestane glycoside from Galtonia candicans [J].

Kuroda, M ;

Mimaki, Y ;

Sashida, Y ;

Yamori, T ;

Tsuruo, T .

TETRAHEDRON LETTERS, 2000, 41 (02) :251-255

[8] New furostanol glycosides from the rhizomes of Dioscorea futschauensis R. Kunth [J].

Liu, HW ;

Wang, SL ;

Cai, B ;

Qu, GX ;

Yang, XJ ;

Kobayashi, H ;

Yao, XS .

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2003, 5 (04) :241-247

[9] Steroidal alkaloid saponins and steroidal saponins from Solanum surattense [J].

Lu, Yuanyuan ;

Luo, Jianguang ;

Kong, Lingyi .

PHYTOCHEMISTRY, 2011, 72 (07) :668-673

[10] Lignans from Santalum album and Their Cytotoxic Activities [J].

Matsuo, Yukiko ;

Mimaki, Yoshihiro .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2010, 58 (04) :587-590

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