Cell engulfment, no sooner ced than done

被引：11

作者：

Conradt, B ^{[1
]}

机构：

[1] Max Planck Inst Neurobiol, D-85152 Martinsried, Germany

来源：

DEVELOPMENTAL CELL | 2001年 / 1卷 / 04期

关键词：

D O I：

10.1016/S1534-5807(01)00065-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Three genes, ced-2, ced-5, and ced-10, are required for both cell corpse engulfment and distal tip cell migration in C. elegans. Recently, a fourth gene, ced-12, has been identified that is required for these two processes. ced-12 encodes a novel, conserved adaptor molecule involved in the activation of Rho/Rac/CDC42-like GTPases.

引用

页码：445 / 447

页数：3

共 7 条

[1] αvβ5 integrin recruits the Crkll-Dock180-Rac1 complex for phagocytosis of apoptotic cells [J].

Albert, ML ;

Kim, JI ;

Birge, RB .

NATURE CELL BIOLOGY, 2000, 2 (12) :899-905

[2] CED-12/ELMO, a novel member of the crkII/dock180/rac pathway, is required for phagocytosis and cell migration [J].

Gumienny, TL ;

Brugnera, E ;

Tosello-Trampont, AC ;

Kinchen, JM ;

Haney, LB ;

Nishiwaki, K ;

Walk, SF ;

Nemergut, ME ;

Macara, IG ;

Francis, R ;

Schedl, T ;

Qin, Y ;

Van Aelst, L ;

Hengartner, MO ;

Ravichandran, KS .

CELL, 2001, 107 (01) :27-41

[3] Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton [J].

Hall, A ;

Nobes, CD .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2000, 355 (1399) :965-970

[4] Apoptosis: Corralling the corpses [J].

Hengartner, MO .

CELL, 2001, 104 (03) :325-328

[5] CED-2/Crkll and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans [J].

Reddien, PW ;

Horvitz, HR .

NATURE CELL BIOLOGY, 2000, 2 (03) :131-136

[6] Corpse clearance defines the meaning of cell death [J].

Savill, J ;

Fadok, V .

NATURE, 2000, 407 (6805) :784-788

[7] C-elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180 [J].

Wu, YC ;

Horvitz, HR .

NATURE, 1998, 392 (6675) :501-504

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