Intermittent energy restriction improves weight loss efficiency in obese men: the MATADOR study

被引:82
作者
Byrne, N. M. [1 ,2 ,3 ]
Sainsbury, A. [4 ]
King, N. A. [2 ,3 ]
Hills, A. P. [1 ,2 ,3 ]
Wood, R. E. [1 ,2 ,3 ]
机构
[1] Univ Tasmania, Sch Hlth Sci, Fac Hlth, Newnham Campus, Launceston, Tas 7250, Australia
[2] Queensland Univ Technol, Sch Exercise & Nutr Sci, Brisbane, Qld, Australia
[3] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia
[4] Univ Sydney, Charles Perkins Ctr, Sydney Med Sch, Boden Inst Obes Nutr Exercise & Eating Disorders, Camperdown, NSW, Australia
基金
澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;
关键词
RESTING METABOLIC-RATE; BODY-COMPOSITION; CALORIC RESTRICTION; EXPENDITURE; ADAPTATION; DIET; WOMEN; INTERVENTION; EXERCISE; HUMANS;
D O I
10.1038/ijo.2017.206
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND/OBJECTIVES: The MATADOR (Minimising Adaptive Thermogenesis And Deactivating Obesity Rebound) study examined whether intermittent energy restriction (ER) improved weight loss efficiency compared with continuous ER and, if so, whether intermittent ER attenuated compensatory responses associated with ER. SUBJECTS/METHODS: Fifty-one men with obesity were randomised to 16 weeks of either: (1) continuous (CON), or (2) intermittent (INT) ER completed as 8 x 2-week blocks of ER alternating with 7 x 2-week blocks of energy balance (30 weeks total). Forty-seven participants completed a 4-week baseline phase and commenced the intervention (CON: N = 23, 39.4 +/- 6.8 years, 111.1 +/- 9.1 kg, 34.3 +/- 3.0 kg m(-2); INT: N = 24, 39.8 +/- 9.5 years, 110.2 +/- 13.8 kg, 34.1 +/- 4.0 kg m(-2)). During ER, energy intake was equivalent to 67% of weight maintenance requirements in both groups. Body weight, fat mass (FM), fat-free mass (FFM) and resting energy expenditure (REE) were measured throughout the study. RESULTS: For the N = 19 CON and N = 17 INT who completed the intervention per protocol, weight loss was greater for INT (14.1 +/- 5.6 vs 9.1 +/- 2.9 kg; P<0.001). INT had greater FM loss (12.3 +/- 4.8 vs 8.0 +/- 4.2 kg; P<0.01), but FFM loss was similar (INT: 1.8 +/- 1.6 vs CON: 1.2 +/- 2.5 kg; P = 0.4). Mean weight change during the 7 x 2-week INT energy balance blocks was minimal (0.0 +/- 0.3 kg). While reduction in absolute REE did not differ between groups (INT: -502 +/- 481 vs CON: -624 +/- 557 kJ d(-1); P = 0.5), after adjusting for changes in body composition, it was significantly lower in INT (INT: -360 +/- 502 vs CON: -749 +/- 498 kJ d(-1); P<0.05). CONCLUSIONS: Greater weight and fat loss was achieved with intermittent ER. Interrupting ER with energy balance 'rest periods' may reduce compensatory metabolic responses and, in turn, improve weight loss efficiency.
引用
收藏
页码:129 / 138
页数:10
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