Thymoquinone Inhibits Biofilm Formation and Attachment-Invasion in Host Cells of Vibrio parahaemolyticus

被引：37

作者：

Guo, Du ^{[1
]}

Yang, Zeyu ^{[1
]}

Zheng, Xiaoying ^{[1
]}

Kang, Shenmin ^{[1
]}

Yang, Zhuokai ^{[1
]}

Xu, Yunfeng ^{[2
]}

Shi, Chao ^{[1
]}

Tian, Hongyu ^{[3
]}

Xia, Xiaodong ^{[1
]}

机构：

[1] Northwest A&F Univ, Coll Food Sci & Engn, 22 Xinong Rd, Yangling 712100, Shaanxi, Peoples R China

[2] Henan Univ Sci & Technol, Coll Food & Bioengn, Luoyang, Peoples R China

[3] Beijing Technol & Business Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing, Peoples R China

来源：

FOODBORNE PATHOGENS AND DISEASE | 2019年 / 16卷 / 10期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Vibrio parahaemolyticus; thymoquinone; virulence factors; subminimum inhibitory concentration; quorum sensing; FOOD CONTACT SURFACES; IN-VITRO; CRONOBACTER-SAKAZAKII; VIRULENCE FACTORS; NIGELLA-SATIVA; ADHESION; EXPRESSION; COMPONENTS; RESISTANCE; AGENT;

D O I：

10.1089/fpd.2018.2591

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Vibrio parahaemolyticus is a halophilic Gram-negative foodborne pathogen that is widely distributed in marine environments. It can cause acute gastroenteritis and other diseases. This study aimed to investigate the antivirulence activity of thymoquinone (TQ) on V. parahaemolyticus. TQ was shown to effectively inhibit V. parahaemolyticus. Subminimum inhibitory concentrations of TQ inhibited swimming and swarming motility, quorum sensing, biofilm formation, the ability of V. parahaemolyticus to adhere and invade the host cells, and the expression of virulence-associated genes of V. parahaemolyticus. These findings suggest that TQ can effectively inhibit the growth of V. parahaemolyticus and significantly reduce its pathogenicity. Considering its safety and various biological activities, TQ has the potential to be developed as a natural antibacterial substance to reduce the diseases associated with V. parahaemolyticus.

引用

页码：671 / 678

页数：8

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