Bub1 is required for maintaining cancer stem cells in breast cancer cell lines

被引：62

作者：

Han, Jeong Yoon ^{[1
]}

Han, Yu Kyeong ^{[1
]}

Park, Ga-Young ^{[1
,2
]}

Kim, Sung Dae ^{[1
]}

Kim, Joong Sun ^{[1
]}

Jo, Wol Soon ^{[1
]}

Lee, Chang Geun ^{[1
]}

机构：

[1] Dongnam Inst Radiol & Med Sci, Res Ctr, Busan 619953, South Korea

[2] Pusan Natl Univ, Coll Nat Sci, Dept Mol Biol, Pusan 609735, South Korea

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

基金：

新加坡国家研究基金会;

关键词：

TUMOR-INITIATING CELLS; THERAPEUTIC TARGET; HYALURONAN; KINASE; RHAMM; EXPRESSION; PROTEIN; AURORA; INSTABILITY; PROGRESSION;

D O I：

10.1038/srep15993

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Breast cancer is a leading cause of death among women worldwide due to therapeutic resistance and cancer recurrence. Cancer stem cells are believed to be responsible for resistance and recurrence. Many efforts to overcome resistance and recurrence by regulating cancer stem cells are ongoing. Bub1 (Budding uninhibited by benzimidazoles 1) is a mitotic checkpoint serine/threonine kinase that plays an important role in chromosome segregation. Bub1 expression is correlated with a poor clinical prognosis in patients with breast cancer. We identified that depleting Bub1 using shRNAs reduces cancer stem cell potential of the MDA-MB-231 breast cancer cell line, resulting in inhibited formation of xenografts in immunocompromised mice. These results suggest that Bub1 may be associated with cancer stem cell potential and could be a target for developing anti-breast cancer stem cell therapies.

引用

页数：8

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