Monocyte Conversion During Inflammation and Injury

被引：361

作者：

Kratofil, Rachel M. ^{[1
]}

Kubes, Paul ^{[1
,2
]}

Deniset, Justin F. ^{[2
]}

机构：

[1] Univ Calgary, Cumming Sch Med, Dept Microbiol Immunol & Infect Dis, Snyder Inst Chron Dis, Calgary, AB T2N 4N1, Canada

[2] Univ Calgary, Cumming Sch Med, Dept Physiol & Pharmacol, Snyder Inst Chron Dis, Calgary, AB T2N 4N1, Canada

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2017年 / 37卷 / 01期

基金：

加拿大健康研究院;

关键词：

infection; inflammation; innate immunity; macrophages; monocytes; ACUTE MYOCARDIAL-INFARCTION; PREDICT CARDIOVASCULAR EVENTS; COLONY-STIMULATING FACTOR; HUMAN PERIPHERAL-BLOOD; DENDRITIC CELLS; BONE-MARROW; RHEUMATOID-ARTHRITIS; BACTERIAL-INFECTION; STEADY-STATE; CHEMOKINE RECEPTOR;

D O I：

10.1161/ATVBAHA.116.308198

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Monocytes are circulating leukocytes important in both innate and adaptive immunity, primarily functioning in immune defense, inflammation, and tissue remodeling. There are 2 subsets of monocytes in mice (3 subsets in humans) that are mobilized from the bone marrow and recruited to sites of inflammation, where they carry out their respective functions in promoting inflammation or facilitating tissue repair. Our understanding of the fate of these monocyte subsets at the site of inflammation is constantly evolving. This brief review highlights the plasticity of monocyte subsets and their conversion during inflammation and injury.

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页码：35 / +

页数：9

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