Chip-scale fluorescence microscope based on a silo-filter complementary metal-oxide semiconductor image sensor

被引:27
|
作者
Lee, Seung Ah [1 ]
Ou, Xiaoze [1 ]
Lee, J. Eugene [2 ]
Yang, Changhuei [1 ]
机构
[1] CALTECH, Dept Elect Engn, Pasadena, CA 91125 USA
[2] Korea Res Inst Stand & Sci, Div Metrol Qual Life, Ctr Bioanal, Taejon 305340, South Korea
关键词
CELL; WIDE;
D O I
10.1364/OL.38.001817
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We demonstrate a silo-filter (SF) complementary metal-oxide semiconductor (CMOS) image sensor for a chip-scale fluorescence microscope. The extruded pixel design with metal walls between neighboring pixels guides fluorescence emission through the thick absorptive filter to the photodiode of a pixel. Our prototype device achieves 13 mu m resolution over a wide field of view (4.8 mm x 4.4 mm). We demonstrate bright-field and fluorescence longitudinal imaging of living cells in a compact, low-cost configuration. (C) 2013 Optical Society of America
引用
收藏
页码:1817 / 1819
页数:3
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