First isolation of a new species of Leishmania responsible for human cutaneous leishmaniasis in Ghana and classification in the Leishmania enriettii complex

被引：52

作者：

Kwakye-Nuako, Godwin ^{[1
,2
]}

Mosore, Mba-Tihssommah ^{[3
,4
]}

Duplessis, Christopher ^{[3
]}

Bates, Michelle D. ^{[1
]}

Puplampu, Naiki ^{[3
]}

Mensah-Attipoe, Israel ^{[5
]}

Desewu, Kwame ^{[6
]}

Afegbe, Godwin ^{[7
]}

Asmah, Richard H. ^{[8
]}

Jamjoom, Manal B. ^{[1
]}

Ayeh-Kumi, Patrick F. ^{[5
,8
]}

Boakye, Daniel A. ^{[4
]}

Bates, Paul A. ^{[1
]}

机构：

[1] Univ Lancaster, Fac Hlth & Med, Div Biomed & Life Sci, Lancaster LA1 4YQ, England

[2] Univ Cape Coast, Sch Biol Sci, Dept Biomed & Forens Sci, Cape Coast, Ghana

[3] Univ Ghana, Noguchi Mem Inst Med Res, US Naval Med Res Unit 3, NAMRU 3, Legon, Accra, Ghana

[4] Univ Ghana, Noguchi Mem Inst Med Res, Dept Parasitol, Legon, Accra, Ghana

[5] Univ Ghana, Sch Med, Dept Microbiol, Legon, Accra, Ghana

[6] Ghana Hlth Serv, Accra, Ghana

[7] Minist Hlth, Dis Control Unit, Ho, Ghana

[8] Univ Ghana, Coll Hlth Sci, Sch Allied Hlth Sci, Korle Bu, Accra, Ghana

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2015年 / 45卷 / 11期

基金：

英国惠康基金;

关键词：

Ghana; Leishmania; Cutaneous leishmaniasis; Phylogeny; FRENCH-WEST-INDIES; GENUS LEISHMANIA; SAND FLIES; DNA; TRYPANOSOMATIDAE; MARTINIQUENSIS; IDENTIFICATION; PARASITES; THAILAND; MEMBER;

D O I：

10.1016/j.ijpara.2015.05.001

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

An active case detection approach with PCR diagnosis was used in the Ho District of the Volta Region, Ghana that identified individuals with active cutaneous leishmaniasis. Three isolates were successfully cultured and DNA sequences from these were analysed (ribosomal RNA internal transcribed spacer 1; ribosomal protein L23a intergenic spacer; RNA polymerase II large subunit), showing them to be Leishmania, identical to each other but different from all other known Leishmania spp. Phylogenetic analysis showed the parasites to be new members of the Leishmania enriettii complex, which is emerging as a possible new subgenus of Leishmania parasites containing human pathogens. (C) 2015 The Authors. Published by Elsevier Ltd.

引用

页码：679 / 684

页数：6

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