Valproic acid pathway: pharmacokinetics and pharmacodynamics

被引：310

作者：

Ghodke-Puranik, Yogita ^{[1
]}

Thorn, Caroline F. ^{[4
]}

Lamba, Jatinder K. ^{[1
,2
]}

Leeder, J. Steven ^{[6
]}

Song, Wen ^{[1
]}

Birnbaum, Angela K. ^{[1
,3
]}

Altman, Russ B. ^{[4
,5
]}

Klein, Teri E. ^{[4
]}

机构：

[1] Univ Minnesota Twin Cities, Dept Expt & Clin Pharmacol, Minneapolis, MN USA

[2] Univ Minnesota Twin Cities, PUMA Inst Personalized Med, Minneapolis, MN USA

[3] Univ Minnesota Twin Cities, Ctr Clin & Cognit Neuropharmacol, Minneapolis, MN USA

[4] Stanford Univ, Med Ctr, Dept Genet, Stanford, CA 94305 USA

[5] Stanford Univ, Med Ctr, Dept Bioengn, Stanford, CA 94305 USA

[6] Childrens Mercy Hosp & Clin, Div Clin Pharmacol & Therapeut Innovat, Kansas City, MO USA

来源：

PHARMACOGENETICS AND GENOMICS | 2013年 / 23卷 / 04期

关键词：

pathway; pharmacodynamics; pharmacogenomics; pharmacokinetics; valproic acid; HUMAN LIVER-MICROSOMES; 2-NORMAL-PROPYL-4-PENTENOIC ACID; INDUCED HYPERAMMONEMIA; METABOLIC-ACTIVATION; IN-VIVO; IDENTIFICATION; CYP2C9; DRUG; POLYMORPHISM; ASSOCIATION;

D O I：

10.1097/FPC.0b013e32835ea0b2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

[No abstract available]

引用

页码：236 / 241

页数：6

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