The Apical Ectodermal Ridge: morphological aspects and signaling pathways

被引：103

作者：

Fernandez-Teran, Marian ^{[1
]}

Ros, Maria A. ^{[1
,2
]}

机构：

[1] Univ Cantabria, Dept Anat & Biol Celular, Santander 39011, Spain

[2] CSIC UC IDICAN, IBBTEC, Inst Biomed & Biotecnol Cantabria, Santander, Spain

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | 2008年 / 52卷 / 07期

关键词：

apical ectodermal ridge; AER; limb development; FGF; dorso-ventral patterning; double ridge;

D O I：

10.1387/ijdb.072416mf

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Apical Ectodermal Ridge (AER) is one of the main signaling centers during limb development. It controls outgrowth and patterning in the proximo-distal axis. In the last few years a considerable amount of new data regarding the cellular and molecular mechanisms underlying AER function and structure has been obtained. In this review, we describe and discuss current knowledge of the regulatory networks which control the induction, maturation and regression of the AER, as well as the link between dorso-ventral patterning and the formation and position of the AER. Our aim is to integrate both recent and old knowledge to produce a wider picture of the AER which enhances our understanding of this relevant structure.

引用

页码：857 / 871

页数：15

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