Design of ellagic acid-loaded chitosan/zein films for wound bandaging

被引：26

作者：

Tavares, Walter S. ^{[1
,2
]}

Tavares-Junior, Alberto G. ^{[1
]}

Otero-Espinar, Francisco J. ^{[3
]}

Martin-Pastor, Manuel ^{[4
]}

Sousa, Francisco F. O. ^{[1
,2
]}

机构：

[1] Univ Fed Amapa, Dept Biol & Hlth Sci, Grad Program Pharmaceut Sci, Rodovia Juscelino Kubitschek,Km 2,Jd Marco Zero, BR-68903419 Macapa, AP, Brazil

[2] Univ Fed Amapa, Dept Biol & Hlth Sci, Grad Program Pharmaceut Innovat, Rodovia Juscelino Kubitschek,Km 2,Jd Marco Zero, BR-68903419 Macapa, AP, Brazil

[3] Univ Santiago de Compostela, Dept Pharm & Pharmaceut Technol, Campus Vida S-N, Santiago De Compostela 15782, Spain

[4] Univ Santiago de Compostela, RIAIDT, CACTUS, Unidade Resonancia Magnet, Campus Vida S-N, Santiago De Compostela 15782, Spain

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2020年 / 59卷

关键词：

Ellagic acid; Chitosan; Zein; Antimicrobial; Films; Wound; IN-VIVO; ZEIN; DELIVERY; NANOPARTICLES; ANTIBACTERIAL; IMPROVEMENT; BARRIER; CHITIN;

D O I：

10.1016/j.jddst.2020.101903

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chitosan/zein films were developed for controlled release of ellagic acid using a central composite design to evaluate the effect of the polymers concentration on the films' characteristics and its application as a wound bandaging platform. The films' characteristics were predicted with quadratic models. Responses were found to depend on the composition of the film, with both polymers exerting a significant influence on the resulting thickness and contact angle (p < 0.05). Zein presented a significant influence on the release of ellagic acid. Furthermore, the obtained films presented suitable thickness, high sorption and controlled release pattern. Most films presented inhibitory activity against Staphylococcus aureus and Pseudomonas aeruginosa in vitro, supporting their use as a bandaging platform with antimicrobial features. These results show that the polymeric films prepared could become a therapeutic option to prevent/treat cutaneous-mucous infections and to aid on the skin rehabilitation.

引用

页数：10

共 48 条

[1] Protective effect of ellagic acid on healing alveolar bone after tooth extraction in rat-A histological and immunohistochemical study [J].