Targeting mechanisms of Pseudomonas aeruginosa pathogenesis

被引：243

作者：

Kipnis, E ^{[1
]}

Sawa, T ^{[1
]}

Wiener-Kronish, J ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Anesthesia & Perioperat Care, San Francisco, CA 94143 USA

来源：

MEDECINE ET MALADIES INFECTIEUSES | 2006年 / 36卷 / 02期

关键词：

Pseudomonas aeruginosa; pathogenicity; virulence factors;

D O I：

10.1016/j.medmal.2005.10.007

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Pseudomonas aeruginosa is an opportunistic pathogen responsible for ventilator-acquired pneumonia, acute lower respiratory tract infections in immunocompromised patients and chronic respiratory infections in cystic fibrosis patients. High incidence, infection severity and increasing resistance characterize P. aeruginosa infections, highlighting the need for new therapeutic options. One such option is to target the many pathogenic mechanisms conferred to P. aeruginosa by its large genome encoding many different virulence factors. This article reviews the pathogenic mechanisms and potential therapies targeting these mechanisms in P. aeruginosa respiratory infections. (c) 2006 Elsevier SAS. All rights reserved.

引用

页码：78 / 91

页数：14

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