Unraveling the environmental and genetic interactions in atherosclerosis: Central role of the gut microbiota

被引：64
作者：
Org, Elin
Mehrabian, Margarete
Lusis, Aldons J.
机构：
[1] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Microbiol, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA 90095 USA
来源：
ATHEROSCLEROSIS | 2015年 / 241卷 / 02期
关键词：
Host-gut microbiota interactions; Mucosal immune system; Trimethylamine-N-oxide; Germ-free mice; Polyphenolic metabolites; Systems biology approach; TRIMETHYLAMINE-N-OXIDE; CHLAMYDIA-PNEUMONIAE INFECTION; BILE-ACID METABOLISM; SMOOTH-MUSCLE-CELLS; C-REACTIVE PROTEIN; L-CARNITINE; INTESTINAL MICROBIOTA; HIGH-FAT; DIETARY-INTAKE; HOST GENOTYPE;
D O I：
10.1016/j.atherosclerosis.2015.05.035
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent studies have convincingly linked gut microbiota to traits relevant to atherosclerosis, such as insulin resistance, dyslipidemia and inflammation, and have revealed novel disease pathways involving microbe-derived metabolites. These results have important implications for understanding how environmental and genetic factors act together to influence cardiovascular disease (CVD) risk. Thus, dietary constituents are not only absorbed and metabolized by the host but they also perturb the gut microbiota, which in turn influence host metabolism and inflammation. It also appears that host genetics helps to shape the gut microbiota community. Here, we discuss challenges in understanding these interactions and the role they play in CVD. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：387 / 399
页数：13
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