Anti-infective Properties of the Golden Spice Curcumin

被引：232

作者：

Praditya, Dimas ^{[1
,2
,3
,4
]}

Kirchhoff, Lisa ^{[5
]}

Bruening, Janina ^{[1
]}

Rachmawati, Heni ^{[6
,7
]}

Steinmann, Joerg ^{[5
,8
]}

Steinmann, Eike ^{[1
]}

机构：

[1] Ruhr Univ Bochum, Dept Mol & Med Virol, Bochum, Germany

[2] Joint Venture Med Sch Hannover, Inst Expt Virol, Twincore Ctr Expt & Clin Infect Res, Hannover, Germany

[3] Helmholtz Ctr Infect Res, Hanover, NH USA

[4] Indonesian Inst Sci, Res Ctr Biotechnol, Cibinong, Indonesia

[5] Univ Duisburg Essen, Univ Hosp Essen, Inst Med Microbiol, Essen, Germany

[6] Bandung Inst Technol, Sch Pharm, Bandung, Indonesia

[7] Bandung Inst Technol, Res Ctr Nanosci & Nanotechnol, Bandung, Indonesia

[8] Paracelsus Med Univ, Inst Clin Hyg Med Microbiol & Infectiol, Klinikum NUmbeng, Nurnberg, Germany

来源：

FRONTIERS IN MICROBIOLOGY | 2019年 / 10卷

关键词：

curcumin; natural products; nutraceutical; anti-infective properties; virus; bacteria; fungi; RESPIRATORY SYNCYTIAL VIRUS; RESISTANT STAPHYLOCOCCUS-AUREUS; HEPATITIS-B-VIRUS; MEDIATED PHOTODYNAMIC INACTIVATION; METHICILLIN-RESISTANT; ANTIBACTERIAL ACTIVITY; IN-VITRO; ANTIMICROBIAL ACTIVITY; SILVER NANOPARTICLES; HELICOBACTER-PYLORI;

D O I：

10.3389/fmicb.2019.00912

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The search for novel anti-infectives is one of the most important challenges in natural product research, as diseases caused by bacteria, viruses, and fungi are influencing the human society all over the world. Natural compounds are a continuing source of novel anti-infectives. Accordingly, curcumin, has been used for centuries in Asian traditional medicine to treat various disorders. Numerous studies have shown that curcumin possesses a wide spectrum of biological and pharmacological properties, acting, for example, as anti-inflammatory, anti-angiogenic and anti-neoplastic, while no toxicity is associated with the compound. Recently, curcumin's antiviral and antibacterial activity was investigated, and it was shown to act against various important human pathogens like the influenza virus, hepatitis C virus, HIV and strains of Staphylococcus, Streptococcus, and Pseudomonas. Despite the potency, curcumin has not yet been approved as a therapeutic antiviral agent. This review summarizes the current knowledge and future perspectives of the antiviral, antibacterial, and antifungal effects of curcumin.

引用

页数：16

共 184 条

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