Immune reconstitution and implications for immunotherapy following haematopoietic stem cell transplantation

被引:78
作者
Williams, Kristen M. [1 ]
Gress, Ronald E. [1 ]
机构
[1] NCI, Expt Transplantat & Immunol Branch, NIH, Bethesda, MD 20892 USA
关键词
immune reconstition; cellular immunotherapy; allogene stem cell transplant; thymus;
D O I
10.1016/j.beha.2008.06.003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Recovery of a fully functional immune system is a slow and often incomplete process following allogen stem cell transplantation. While innate immunity reconstitutes quickly, adaptive B and especially T-cell lymphopoeisis may be compromised for years following transplantation. Ina large part, these immune system deficits are due to the decrease of even absence of thymopoiesis following transplantation. Thereby, T-cell reconstitution initially relies upon expansion of mature donot Tcells a proliferation driven by high cytokine levels and the presence of allo reactive antigens. this peripheral mechanism of T-cell generation may have important clinical consequences. By expanding tumouricidal T cells it may provide a venue to enhance T-cellular immunotherapy following transplantation. Alternatively, decreased thymic function may impair long-term anti-tumour immunity and increase the likelihood of graft-versus-host diseases.
引用
收藏
页码:579 / 596
页数:18
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