European guidelines for diagnosis and treatment of adenovirus infection in leukemia and stem cell transplantation: summary of ECIL-4 (2011)

被引：197

作者：

Matthes-Martin, S. ^{[2
]}

Feuchtinger, T. ^{[3
]}

Shaw, P. J. ^{[4
]}

Engelhard, D. ^{[5
]}

Hirsch, H. H. ^{[6
]}

Cordonnier, C. ^{[7
,8
]}

Ljungman, P. ^{[1
,9
]}

机构：

[1] Karolinska Univ Hosp, Dept Hematol, S-141861 Stockholm, Sweden

[2] Med Univ, Dept Pediat, Stem Cell Transplantat Unit, St Anna Childrens Hosp, Vienna, Austria

[3] Univ Tubingen Hosp, Dept Pediat, Tubingen, Germany

[4] Childrens Hosp Westmead, Oncol Unit, Sydney, NSW, Australia

[5] Hadassah Univ Hosp, Dept Pediat, IL-91120 Jerusalem, Israel

[6] Univ Basel Hosp, Dept Virol, CH-4031 Basel, Switzerland

[7] Hop Henri Mondor, Assistance Publ Hop Paris, Dept Hematol, F-94010 Creteil, France

[8] Univ Paris Est Creteil, Creteil, France

[9] Karolinska Inst, Dept Med Huddinge, Sect Hematol, Stockholm, Sweden

来源：

TRANSPLANT INFECTIOUS DISEASE | 2012年 / 14卷 / 06期

关键词：

human adenovirus; leukemia; stem cell; guidelines; REAL-TIME PCR; BONE-MARROW-TRANSPLANTATION; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHRONIC LYMPHOCYTIC-LEUKEMIA; POLYMERASE-CHAIN-REACTION; PERIPHERAL-BLOOD; PEDIATRIC-PATIENTS; T-CELLS; IMMUNE RECONSTITUTION; REDUCED-INTENSITY;

D O I：

10.1111/tid.12022

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human adenovirus (HAdV) infections are increasingly recognized as important pathogens in immunocompromised hosts, especially in patients with severely suppressed T-cell function. The 4th European Conference of Infections in Leukemia (ECIL-4) has developed evidence-based guidelines for diagnosis and management of HAdV infections. The risk for HAdV-associated disease is increased in children, and risk factors for HAdV disease are T-cell depletion, unrelated and cord blood hematopoietic stem cell transplantation, graft-versus-host disease grades IIIIV, and lymphopenia. The recommended technique for monitoring of high-risk patients is quantitative polymerase chain reaction. Cidofovir is the most used antiviral therapy, although no controlled study has been performed. HAdV-specific T-cell therapy is in development.

引用

页码：555 / 563

页数：9

共 114 条

[21] Quantification of human herpesvirus 6 in immunocompetent persons and post-mortem tissues from AIDS patients by PCR [J].

Clark, DA ;

AitKhaled, M ;

Wheeler, AC ;

Kidd, IM ;

McLaughlin, JE ;

Johnson, MA ;

Griffiths, PD ;

Emery, VC .

JOURNAL OF GENERAL VIROLOGY, 1996, 77 :2271-2275

[22] T-cell lines specific for peptides of adenovirus hexon protein and devoid of alloreactivity against recipient cells can be obtained from HLA-haploidentical donors [J].

Comoli, Patrizia ;

Schilham, Marco W. ;

Basso, Sabrina ;

van Vreeswijk, Tamara ;

Bernardo, Maria Ester ;

Maccario, Rita ;

van Tol, Maarten J. D. ;

Locatelli, Franco ;

Veltrop-Duits, Louise A. .

JOURNAL OF IMMUNOTHERAPY, 2008, 31 (06) :529-536

[23] The first European conference on infections in leukaemia: Why and how? [J].

Cordonnier, Catherine ;

Calandra, Thierry .

EJC SUPPLEMENTS, 2007, 5 (02) :2-4

[24] Infectious complications after autologous CD34-selected peripheral blood stem cell transplantation [J].

Crippa, F ;

Holmberg, L ;

Carter, RA ;

Hooper, H ;

Marr, KA ;

Bensinger, W ;

Chauncey, T ;

Corey, L ;

Boeckh, M .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2002, 8 (05) :281-289

[25] Adenoviruses from human immunodeficiency virus-infected individuals, including two strains that represent new candidate serotypes Ad50 and Ad51 of species B1 and D, respectively [J].

De Jong, JC ;

Wermenbol, AG ;

Verweij-Uijterwaal, MW ;

Slaterus, KW ;

Wertheim-Van Dillen, P ;

Van Doornum, GJJ ;

Khoo, SH ;

Hierholzer, JC .

JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (12) :3940-3945

[26] Treatment with ganciclovir of adenovirus pneumonia in a cardiac transplant patient [J].

Duggan, JM ;

Farrehi, J ;

Duderstadt, S ;

Turner, NJ ;

Fekety, R .

AMERICAN JOURNAL OF MEDICINE, 1997, 103 (05) :439-440

[27] Molecular detection and quantitative analysis of the entire spectrum of human adenoviruses by a two-reaction real-time PCR assay [J].

Ebner, K ;

Suda, M ;

Watzinger, F ;

Lion, T .

JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (07) :3049-3053

[28] Prediction of severe disseminated adenovirus infection by serum PCR [J].

Echavarria, M ;

Forman, M ;

van Tol, MJD ;

Vossen, JM ;

Charache, P ;

Kroes, ACM .

LANCET, 2001, 358 (9279) :384-385

[29] Adenoviruses in Immunocompromised Hosts [J].

Echavarria, Marcela .

CLINICAL MICROBIOLOGY REVIEWS, 2008, 21 (04) :704-715

[30] Quantitative real-time polymerase chain reaction for detection of adenovirus after T cell-replete hematopoietic cell transplantation: Viral load as a marker for invasive disease [J].

Erard, Veronique ;

Huang, Meei-Li ;

Ferrenberg, James ;

Nguy, Long ;

Stevens-Ayers, Terry L. ;

Hackman, Robert C. ;

Corey, Lawrence ;

Boeckh, Michael .

CLINICAL INFECTIOUS DISEASES, 2007, 45 (08) :958-965

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