European guidelines for diagnosis and treatment of adenovirus infection in leukemia and stem cell transplantation: summary of ECIL-4 (2011)

被引：197

作者：

Matthes-Martin, S. ^{[2
]}

Feuchtinger, T. ^{[3
]}

Shaw, P. J. ^{[4
]}

Engelhard, D. ^{[5
]}

Hirsch, H. H. ^{[6
]}

Cordonnier, C. ^{[7
,8
]}

Ljungman, P. ^{[1
,9
]}

机构：

[1] Karolinska Univ Hosp, Dept Hematol, S-141861 Stockholm, Sweden

[2] Med Univ, Dept Pediat, Stem Cell Transplantat Unit, St Anna Childrens Hosp, Vienna, Austria

[3] Univ Tubingen Hosp, Dept Pediat, Tubingen, Germany

[4] Childrens Hosp Westmead, Oncol Unit, Sydney, NSW, Australia

[5] Hadassah Univ Hosp, Dept Pediat, IL-91120 Jerusalem, Israel

[6] Univ Basel Hosp, Dept Virol, CH-4031 Basel, Switzerland

[7] Hop Henri Mondor, Assistance Publ Hop Paris, Dept Hematol, F-94010 Creteil, France

[8] Univ Paris Est Creteil, Creteil, France

[9] Karolinska Inst, Dept Med Huddinge, Sect Hematol, Stockholm, Sweden

来源：

TRANSPLANT INFECTIOUS DISEASE | 2012年 / 14卷 / 06期

关键词：

human adenovirus; leukemia; stem cell; guidelines; REAL-TIME PCR; BONE-MARROW-TRANSPLANTATION; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHRONIC LYMPHOCYTIC-LEUKEMIA; POLYMERASE-CHAIN-REACTION; PERIPHERAL-BLOOD; PEDIATRIC-PATIENTS; T-CELLS; IMMUNE RECONSTITUTION; REDUCED-INTENSITY;

D O I：

10.1111/tid.12022

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human adenovirus (HAdV) infections are increasingly recognized as important pathogens in immunocompromised hosts, especially in patients with severely suppressed T-cell function. The 4th European Conference of Infections in Leukemia (ECIL-4) has developed evidence-based guidelines for diagnosis and management of HAdV infections. The risk for HAdV-associated disease is increased in children, and risk factors for HAdV disease are T-cell depletion, unrelated and cord blood hematopoietic stem cell transplantation, graft-versus-host disease grades IIIIV, and lymphopenia. The recommended technique for monitoring of high-risk patients is quantitative polymerase chain reaction. Cidofovir is the most used antiviral therapy, although no controlled study has been performed. HAdV-specific T-cell therapy is in development.

引用

页码：555 / 563

页数：9

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