Mimicking the active site of aldehyde dehydrogenases: stabilization of carbonyl hydrates through hydrogen bonds

被引：8
|
作者：
Roth, A. J. K. [1 ]
Tretbar, M. [1 ]
Stark, C. B. W. [1 ]
机构：
[1] Univ Hamburg, Inst Organ Chem, Fachbereich Chem, D-20146 Hamburg, Germany
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 75期
关键词：
CELLULOSE ORGANIC-SOLVENTS; CARBOXYLIC-ACIDS; PRIMARY ALCOHOLS; N-OXIDE; CRYSTAL-STRUCTURE; TETRAPROPYLAMMONIUM PERRUTHENATE; HISTIDINOL DEHYDROGENASE; CATALYTIC MECHANISM; SELECTIVE OXIDATION; MOLECULAR-DYNAMICS;
D O I：
10.1039/c5cc02831k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Aldehyde hydrates are important but highly unstable, transient intermediates in biological and synthetic oxidations to carboxylic acids. We here report N-oxides as the first class of chemical reagents capable of stabilizing such water adducts. This stabilizing effect (studied in solution and in the solid state) seems to be based on the formation of hydrogen bonds.
引用
收藏
页码：14175 / 14178
页数：4
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