Crosstalk between the antioxidant and cell wall integrity systems in fungi by 2-hydroxy-4-methoxybenzaldehyde

被引：1

作者：

Kim, Jong H. ^{[1
]}

Chan, Kathleen L. ^{[1
]}

Tam, Christina C. ^{[1
]}

Cheng, Luisa W. ^{[1
]}

Land, Kirkwood M. ^{[2
]}

机构：

[1] USDA ARS, Foodborne Toxin Detect & Prevent Res Unit, Western Reg Res Ctr, 800 Buchanan St, Albany, CA 94710 USA

[2] Univ Pacific, Dept Biol Sci, Stockton, CA USA

来源：

COGENT FOOD & AGRICULTURE | 2020年 / 6卷 / 01期

关键词：

antifungal intervention; stress signaling; superoxide dismutase; SACCHAROMYCES-CEREVISIAE; NATURAL-PRODUCTS; STRESS; BIOSYNTHESIS; HOG1;

D O I：

10.1080/23311932.2020.1823593

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

We would like to comment on a recent study where the redox-modulatory anti-protozoal drug chloroquine has shown to trigger a crosstalk between the antioxidant and cell wall integrity systems in the yeastSaccharomyces cerevisiae. This note discusses the redox-active potential of the natural compound 2-hydroxy-4-methoxybenzaldehyde (2H4M) which could also serve as a potent redox-cycler in fungal (yeast, molds) pathogens. UsingS. cerevisiaeas a molecular tool, we determined how 2H4M negatively affected both the antioxidant and cell wall integrity systems of fungi, thus indicating a similar crosstalk between the two systems under 2H4M-induced toxicity. The crosstalk functions as a fungal defense against redox-active drugs/compounds or environmental cues, and therefore, could be an effective target for antifungal treatment.

引用

页数：7

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