Glioma: What is the role of c-Myc, hsp90 and telomerase?

被引：32
作者：
Shervington, A [1 ]
Cruickshanks, N
Wright, H
Atkinson-Dell, R
Lea, R
Roberts, G
Shervington, L
机构：
[1] Univ Cent Lancashire, Dept Biol Sci, Preston PR1 2HE, Lancs, England
[2] Royal Preston Hosp, Preston, Lancs, England
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2006年 / 283卷 / 1-2期
关键词：
Chaperones; gene expression; glioma; telomerase; silencing;
D O I：
10.1007/s11010-006-2495-z
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The continuous advancements in cancer research have contributed to the overwhelming evidence of the presence of telomerase in primary and secondary tumours together with hsp90 and c-Myc. This review will discuss the important role of telomerase together with hsp90 and c-Myc within the initiation and progression of gliomas. Also it will review the differential expression of these genes in the different grades of gliomas and the possibility of new treatments targeting these specific genes.
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页码：1 / 9
页数：9
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