Glioma: What is the role of c-Myc, hsp90 and telomerase?

被引：32
作者：
Shervington, A [1 ]
Cruickshanks, N
Wright, H
Atkinson-Dell, R
Lea, R
Roberts, G
Shervington, L
机构：
[1] Univ Cent Lancashire, Dept Biol Sci, Preston PR1 2HE, Lancs, England
[2] Royal Preston Hosp, Preston, Lancs, England
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2006年 / 283卷 / 1-2期
关键词：
Chaperones; gene expression; glioma; telomerase; silencing;
D O I：
10.1007/s11010-006-2495-z
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The continuous advancements in cancer research have contributed to the overwhelming evidence of the presence of telomerase in primary and secondary tumours together with hsp90 and c-Myc. This review will discuss the important role of telomerase together with hsp90 and c-Myc within the initiation and progression of gliomas. Also it will review the differential expression of these genes in the different grades of gliomas and the possibility of new treatments targeting these specific genes.
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页码：1 / 9
页数：9
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共 67 条
  • [1] The c-myc activation in cervical carcinomas and HPV 16 infections
    Abba, MC
    Laguens, RM
    Dulout, FN
    Golijow, CD
    [J]. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2004, 557 (02) : 151 - 158
  • [2] Telomeres, telomerase, and telomerase inhibition: Clinical implications for cancer
    Ahmed, A
    Tollefsbol, T
    [J]. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2003, 51 (01) : 116 - 122
  • [3] Heat, heat shock, heat shock proteins and death: a central link in innate and adaptive immune responses
    Anderson, KM
    Srivastava, PK
    [J]. IMMUNOLOGY LETTERS, 2000, 74 (01) : 35 - 39
  • [4] Primary brain tumours in adults
    Behin, A
    Hoang-Xuan, K
    Carpentier, AF
    Delattre, JY
    [J]. LANCET, 2003, 361 (9354) : 323 - 331
  • [5] Purification and characterization of prokaryotic and eukaryotic Hsp90
    Buchner, J
    Bose, S
    Mayr, C
    Jakob, U
    [J]. MOLECULAR CHAPERONES, 1998, 290 : 409 - 418
  • [6] Purification of Hsp90 partner proteins Hop/p60, p23, and FKBP52
    Buchner, J
    Weikl, T
    Bügl, H
    Pirkl, F
    Bose, S
    [J]. MOLECULAR CHAPERONES, 1998, 290 : 418 - 429
  • [7] Current and future strategies for the treatment of malignant brain tumors
    Castro, MG
    Cowen, R
    Williamson, IK
    David, A
    Jimenez-Dalmaroni, MJ
    Yuan, X
    Bigliari, A
    Williams, JC
    Hu, J
    Lowenstein, PR
    [J]. PHARMACOLOGY & THERAPEUTICS, 2003, 98 (01) : 71 - 108
  • [8] Differential regulation of telomerase activity by six telomerase subunits
    Chang, JTC
    Chen, YL
    Yang, HT
    Chen, CY
    Cheng, AJ
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 2002, 269 (14): : 3442 - 3450
  • [9] Telomerase activity in human hepatocellular carcinoma: parallel correlation with human telomerase reverse transcriptase (hTERT) mRNA isoform expression but not with cell cycle modulators or c-Myc expression
    Chen, CJ
    Tsai, NM
    Liu, YC
    Ho, LI
    Hsieh, HF
    Yen, CY
    Harn, HJ
    [J]. EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, 2002, 28 (03): : 225 - 234
  • [10] Hsp90: the vulnerable chaperone
    Chiosis, G
    Vilenchik, M
    Kim, J
    Solit, D
    [J]. DRUG DISCOVERY TODAY, 2004, 9 (20) : 881 - 888
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