Relative bioavailability estimation of carbamazepine crystal forms using an artificial stomach-duodenum model

被引：110

作者：

Carino, SR ^{[1
]}

Sperry, DC ^{[1
]}

Hawley, M ^{[1
]}

机构：

[1] Pfizer COrp, Michigan Pharmaceut Sci, Kalamazoo, MI 49001 USA

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 2006年 / 95卷 / 01期

关键词：

carbamazepine; solid forms; dissolution; bioavailability; in vitro models; solubility; solid state; thermodynamics; preformulation; polymorphs;

D O I：

10.1002/jps.20495

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The in vitro dissolution of carbamazepine (CBZ) was investigated using an automated artificial stomach-duodenum (ASD) model. Successful simulation of the dog physiology in the fasted state showed that the rank order of the ASD estimated bioavailabilities is as follows: Form III > Form I > dihydrate. This result is in excellent agreement with those found in literature. Additional simulations comparing different gastric transit times during fasted and fed states are also discussed. (c) 2005 Wiley-Liss, Inc.

引用

页码：116 / 125

页数：10

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