Cancer Risk Following Bariatric Surgery-Systematic Review and Meta-analysis of National Population-Based Cohort Studies

被引：78
作者：
Wiggins, Tom [1 ]
Antonowicz, Stefan S. [1 ]
Markar, Sheraz R. [1 ]
机构：
[1] Imperial Coll London, St Marys Hosp, Dept Surg & Canc, Acad Surg Unit, 10th Floor,QEQM Bldg,Praed St, London W2 1NY, England
来源：
OBESITY SURGERY | 2019年 / 29卷 / 03期
关键词：
Bariatric surgery; Cancer; Obesity-related cancer; CAUSE-SPECIFIC MORTALITY; BODY-MASS INDEX; OBESITY SURGERY; OVERWEIGHT;
D O I：
10.1007/s11695-018-3501-8
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
This study has analyzed results from registry-based population studies to assess the effect of bariatric surgery upon cancer incidence at a population level. Relevant studies were identified and meta-analysis was used to calculate pooled odds ratios (POR) for the incidence of cancer after bariatric surgery compared to controls. Eight population-based studies were included with 635,642 total patients. Bariatric surgery was associated with a significant reduction in overall cancer incidence (POR = 0.72; 95% CI 0.59 to 0.87; p = 0.0007) and incidence of obesity-related cancer (POR = 0.55; 95% CI 0.31 to 0.96; p = 0.04). Bariatric surgery was also protective for breast cancer development (POR = 0.50; 95% CI 0.25 to 0.99; p = 0.045). Bariatric surgery appears to be associated with a reduction in cancer incidence at a population-based level.
引用
收藏
页码：1031 / 1039
页数：9
相关论文
共 31 条
[11]   Rectal epithelial cell mitosis and expression of macrophage migration inhibitory factor are increased 3 years after Roux-en-Y gastric bypass (RYGB) for morbid obesity: implications for long-term neoplastic risk following RYGB [J].
Kant, Prashant ;
Sainsbury, Anita ;
Reed, Karen R. ;
Pollard, Stephen G. ;
Scott, Nigel ;
Clarke, Alan R. ;
Coletta, P. Louise ;
Hull, Mark A. .
GUT, 2011, 60 (07) :893-901
[12]   Adiposity and cancer at major anatomical sites: umbrella review of the literature [J].
Kyrgiou, Maria ;
Kalliala, Ilkka ;
Markozannes, Georgios ;
Gunter, Marc J. ;
Paraskevaidis, Evangelos ;
Gabra, Hani ;
Martin-Hirsch, Pierre ;
Tsilidis, Konstantinos K. .
BMJ-BRITISH MEDICAL JOURNAL, 2017, 356
[13]  
Mackenzie H, 2018, BRIT J SURG
[14]   Esophageal adenocarcinoma after obesity surgery in a population-based cohort study [J].
Maret-Ouda, John ;
Tao, Wenjing ;
Mattsson, Fredrik ;
Brusselaers, Nele ;
El-Serag, Hashem B. ;
Lagergren, Jesper .
SURGERY FOR OBESITY AND RELATED DISEASES, 2017, 13 (01) :28-34
[15]   Cancer in Obese Women: Potential Protective Impact of Bariatric Surgery [J].
McCawley, Gwyneth M. ;
Ferriss, J. Stuart ;
Geffel, Dyanna ;
Northup, C. Joe ;
Modesitt, Susan C. .
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2009, 208 (06) :1093-1098
[16]  
NHS Digital, STAT OB PHYS ACT DIE
[17]   Risk of Obesity-Related Cancer After Obesity Surgery in a Population-Based Cohort Study [J].
Ostlund, Magdalena Plecka ;
Lu, Yunxia ;
Lagergren, Jesper .
ANNALS OF SURGERY, 2010, 252 (06) :972-976
[18]   The role of bile acids in reducing the metabolic complications of obesity after bariatric surgery: a systematic review [J].
Penney, N. C. ;
Kinross, J. ;
Newton, R. C. ;
Purkayastha, S. .
INTERNATIONAL JOURNAL OF OBESITY, 2015, 39 (11) :1565-1574
[19]   General and Abdominal Adiposity and Risk of Death in Europe [J].
Pischon, T. ;
Boeing, H. ;
Hoffmann, K. ;
Bergmann, M. ;
Schulze, M. B. ;
Overvad, K. ;
van der Schouw, Y. T. ;
Spencer, E. ;
Moons, K. G. M. ;
Tjonneland, A. ;
Halkjaer, J. ;
Jensen, M. K. ;
Stegger, J. ;
Clavel-Chapelon, F. ;
Boutron-Ruault, M. -C. ;
Chajes, V. ;
Linseisen, J. ;
Kaaks, R. ;
Trichopoulou, A. ;
Trichopoulos, D. ;
Bamia, C. ;
Sieri, S. ;
Palli, D. ;
Tumino, R. ;
Vineis, P. ;
Panico, S. ;
Peeters, P. H. M. ;
May, A. M. ;
Bueno-de-Mesquita, H. B. ;
van Duijnhoven, F. J. B. ;
Hallmans, G. ;
Weinehall, L. ;
Manjer, J. ;
Hedblad, B. ;
Lund, E. ;
Agudo, A. ;
Arriola, L. ;
Barricarte, A. ;
Navarro, C. ;
Martinez, C. ;
Quiros, J. R. ;
Key, T. ;
Bingham, S. ;
Khaw, K. T. ;
Boffetta, P. ;
Jenab, M. ;
Ferrari, P. ;
Riboli, E. .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (20) :2105-2120
[20]   Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies [J].
Renehan, Andrew G. ;
Tyson, Margaret ;
Egger, Matthias ;
Heller, Richard F. ;
Zwahlen, Marcel .
LANCET, 2008, 371 (9612) :569-578
1234