Renal denervation to treat resistant hypertension: Guarded optimism

被引:20
作者
Thomas, George [1 ]
Shishehbor, Mehdi H. [2 ]
Bravo, Emmanuel L. [1 ]
Nally, Joseph V., Jr. [1 ]
机构
[1] Cleveland Clin, Dept Nephrol & Hypertens, Glickman Urol & Kidney Inst, Q7,9500 Euclid Ave, Cleveland, OH 44195 USA
[2] Cleveland Clin, Dept Cardiovasc Med, Inst Heart & Vasc, Cleveland, OH 44195 USA
关键词
SYMPATHETIC DENERVATION; BLOOD-PRESSURE; SPIRONOLACTONE; PATHOGENESIS; PREVALENCE; COMMITTEE;
D O I
10.3949/ccjm.79a.12040
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Renal sympathetic denervation has shown promise in treating hypertension resistant to drug therapy. This procedure lowers blood pressure via targeted attenuation of renal sympathetic tone, and it has a favorable safety profile. But although there is reason for cautious optimism, we should keep in mind that the mechanisms of hypertension are complex and multifactorial, and further study of this novel therapy and its long-term effects is needed.
引用
收藏
页码:501 / 510
页数:10
相关论文
共 33 条
[1]   Renal Sympathetic Denervation Reduces Left Ventricular Hypertrophy and Improves Cardiac Function in Patients With Resistant Hypertension [J].
Brandt, Mathias C. ;
Mahfoud, Felix ;
Reda, Sara ;
Schirmer, Stephan H. ;
Erdmann, Erland ;
Boehm, Michael ;
Hoppe, Uta C. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 59 (10) :901-909
[2]   Resistant hypertension: Diagnosis, evaluation, and treatment - A Scientific Statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research [J].
Calhoun, David A. ;
Jones, Daniel ;
Textor, Stephen ;
Goff, David C. ;
Murphy, Timothy P. ;
Toto, Robert D. ;
White, Anthony ;
Cushman, William C. ;
White, William ;
Sica, Domenic ;
Ferdinand, Keith ;
Giles, Thomas D. ;
Falkner, Bonita ;
Carey, Robert M. .
HYPERTENSION, 2008, 51 (06) :1403-1419
[3]   Reactive oxygen species stimulate central and peripheral sympathetic nervous system activity [J].
Campese, VM ;
Ye, SH ;
Zhong, HQ ;
Yanamadala, V ;
Ye, Z ;
Chiu, J .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2004, 287 (02) :H695-H703
[4]   Neurogenic factors and hypertension in renal disease [J].
Campese, VM .
KIDNEY INTERNATIONAL, 2000, 57 :S2-S6
[5]   Effect of spironolactone on blood pressure in subjects with resistant hypertension [J].
Chapman, Neil ;
Dobson, Joanna ;
Wilson, Sarah ;
Dahlof, Bjorn ;
Sever, Peter S. ;
Wedel, Hans ;
Poulter, Neil R. .
HYPERTENSION, 2007, 49 (04) :839-845
[6]   Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure [J].
Chobanian, AV ;
Bakris, GL ;
Black, HR ;
Cushman, WC ;
Green, LA ;
Izzo, JL ;
Jones, DW ;
Materson, BJ ;
Oparil, S ;
Wright, JT ;
Roccella, EJ .
HYPERTENSION, 2003, 42 (06) :1206-1252
[7]   US Trends in Prevalence, Awareness, Treatment, and Control of Hypertension, 1988-2008 [J].
Egan, Brent M. ;
Zhao, Yumin ;
Axon, R. Neal .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 303 (20) :2043-2050
[8]   Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial [J].
Esler, Murray D. ;
Krum, Henry ;
Sobotka, Paul A. ;
Schlaich, Markus P. ;
Schmieder, Roland E. ;
Boehm, Michael ;
Mahfoud, Felix ;
Sievert, Horst ;
Wunderlich, Nina ;
Rump, Lars Christian ;
Vonend, Oliver ;
Uder, Michael ;
Lobo, Mel ;
Caulfield, Mark ;
Erglis, Andrejs ;
Azizi, Michel ;
Sapoval, Marc ;
Thambar, Suku ;
Persu, Alexandre ;
Renkin, Jean ;
Schunkert, Heribert ;
Weil, Joachim ;
Hoppe, Uta C. ;
Walton, Tony ;
Scheinert, Dierk ;
Binder, Thomas ;
Januszewicz, Andrzej ;
Witkowski, Adam ;
Ruilope, Luis M. ;
Whitbourn, Robert ;
Bruck, Heike ;
Downes, Mark ;
Luescher, Thomas F. ;
Jardine, Alan G. ;
Webster, Mark W. ;
Zeller, Thomas ;
Sadowski, Jerzy ;
Bartus, Krzysztof ;
Straley, Craig A. ;
Barman, Neil C. ;
Lee, David P. ;
Witteles, Ronald M. ;
Bhalla, Vivek ;
Massaro, Joseph M. .
LANCET, 2010, 376 (9756) :1903-1909
[9]   Renal Denervation in Moderate to Severe CKD [J].
Hering, Dagmara ;
Mahfoud, Felix ;
Walton, Antony S. ;
Krum, Henry ;
Lambert, Gavin W. ;
Lambert, Elisabeth A. ;
Sobotka, Paul A. ;
Boehm, Michael ;
Cremers, Bodo ;
Esler, Murray D. ;
Schlaich, Markus P. .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2012, 23 (07) :1250-1257
[10]  
Kandzari DE, 2012, CLIN CARDIOL 0509