A concise and traceless linker strategy toward combinatorial libraries of 2,6,9-substituted purines

被引:56
作者
Ding, S
Gray, NS
Ding, Q
Schultz, PG
机构
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[3] Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
关键词
D O I
10.1021/jo016010f
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:8273 / 8276
页数:4
相关论文
共 22 条
[1]  
Adams J L, 1999, Curr Opin Drug Discov Devel, V2, P96
[2]   PREPARATION AND APPLICATION OF THE 5-(4-(9-FLUORENYLMETHYLOXYCARBONYL)AMINOMETHYL-3,5-DIMETHOXYPHENOXY)VALERIC ACID (PAL) HANDLE FOR THE SOLID-PHASE SYNTHESIS OF C-TERMINAL PEPTIDE AMIDES UNDER MILD CONDITIONS [J].
ALBERICIO, F ;
KNEIBCORDONIER, N ;
BIANCALANA, S ;
GERA, L ;
MASADA, RI ;
HUDSON, D ;
BARANY, G .
JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (12) :3730-3743
[3]   Solid-phase synthesis of 1,4-benzodiazepine-2,5-diones. Library preparation and demonstration of synthesis generality [J].
Boojamra, CG ;
Burow, KM ;
Thompson, LA ;
Ellman, JA .
JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (05) :1240-1256
[4]   Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors [J].
Chang, YT ;
Gray, NS ;
Rosania, GR ;
Sutherlin, DP ;
Kwon, S ;
Norman, TC ;
Sarohia, R ;
Leost, M ;
Meijer, L ;
Schultz, PG .
CHEMISTRY & BIOLOGY, 1999, 6 (06) :361-375
[5]   The development and therapeutic potential of protein kinase inhibitors [J].
Cohen, P .
CURRENT OPINION IN CHEMICAL BIOLOGY, 1999, 3 (04) :459-465
[6]   REGIOSPECIFIC ALKYLATION OF 6-CHLOROPURINE AND 2,6-DICHLOROPURINE AT N7 BY TRANSIENT PROTECTION OF N3/N9 BY METHYLCOBALOXIME [J].
DALBY, C ;
BLEASDALE, C ;
CLEGG, W ;
ELSEGOOD, MRJ ;
GOLDING, BT ;
GRIFFIN, RJ .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1993, 32 (12) :1696-1697
[7]   Novel solid-phase preparation of 2,6,9-trisubstituted purines for combinatorial library generation [J].
Dorff, PH ;
Garigipati, RS .
TETRAHEDRON LETTERS, 2001, 42 (15) :2771-2773
[8]   Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells [J].
Druker, BJ ;
Tamura, S ;
Buchdunger, E ;
Ohno, S ;
Segal, GM ;
Fanning, S ;
Zimmermann, J ;
Lydon, NB .
NATURE MEDICINE, 1996, 2 (05) :561-566
[9]  
García-Echeverría C, 2000, MED RES REV, V20, P28, DOI 10.1002/(SICI)1098-1128(200001)20:1<28::AID-MED2>3.0.CO
[10]  
2-2