Atherosclerosis;
Magnetic Resonance Imaging;
Ultrafine Superparamagnetic Iron Oxide;
Animal Experiments;
DNA;
INFLAMMATION;
MECHANISMS;
EXTRACTION;
D O I:
10.1166/jnn.2020.18882
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
Unstable atherosclerotic (AS) plaques contain numerous macrophages that can phagocytose a specific contrast agent, namely ultrafine superparamagnetic iron oxide (USPIO). This study prepared USPIO nanoparticles, defined their physical and magnetic properties and transmission characteristics, explored the feasibility of their use as a magnetic resonance negative contrast agent, and used them to detect unstable AS plaque as a specific marker of macrophages. We randomly divided 20 healthy male New Zealand white rabbits into two groups, experimental and control (n = 10 each). The experimental group was fed pure high-fat feed. The magnetic resonance imaging (MRI) performance of arterial plaque before and after USPIO enhancement compare with pathological results. The experimental group successfully established a rabbit AS plaque model, and 8 of 10 rabbits developed AS plaque. USPIO-enhanced T2W1 sequence showed that the central signal of the plaque was reduced, and the signal-to-noise ratio of the vascular wall was the lowest at 96 h. The control group showed no change in the wall signal before and after enhancement. The USPIO-enhanced PJN2D-TOF sequence showed dotted filling defects on the tube wall. Pathological examination showed that USPIO nanoparticles were mainly deposited under the arterial intima. A simple high-fat diet can establish a rabbit AS plaque model, and USPIO-enhanced MRI reflects the condition of rabbit AS plaque, which is helpful in evaluating AS lesion diagnosis.
机构:
Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia
Univ New South Wales, Sch Med Sci, Fac Med, Sydney, NSW 2052, Australia
Univ Western Sydney, Sch Med, Campbelltown, NSW 2560, AustraliaRussian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia
Bobryshev, Yuri V.
Ivanova, Ekaterina A.
论文数: 0引用数: 0
h-index: 0
机构:
Katholieke Univ Leuven, Dept Dev & Regenerat, B-3000 Leuven, BelgiumRussian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia
Ivanova, Ekaterina A.
Chistiakov, Dimitry A.
论文数: 0引用数: 0
h-index: 0
机构:
Res Ctr Childrens Hlth, Inst Pediat, Dept Mol Genet Diagnost & Cell Biol, Moscow 119991, RussiaRussian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia
Chistiakov, Dimitry A.
Nikiforov, Nikita G.
论文数: 0引用数: 0
h-index: 0
机构:
Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia
Skolkovo Innovat Ctr, Inst Atherosclerosis, Moscow 143025, RussiaRussian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia
Nikiforov, Nikita G.
Orekhov, Alexander N.
论文数: 0引用数: 0
h-index: 0
机构:
Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia
Skolkovo Innovat Ctr, Inst Atherosclerosis, Moscow 143025, Russia
Moscow MV Lomonosov State Univ, Fac Biol, Dept Biophys, Moscow 119991, RussiaRussian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia
机构:
CNR, Inst Biostruct & Bioimaging, Via T De Amicis 95, I-80145 Naples, ItalyCNR, Inst Biostruct & Bioimaging, Via T De Amicis 95, I-80145 Naples, Italy
Gargiulo, Sara
Gramanzini, Matteo
论文数: 0引用数: 0
h-index: 0
机构:
CNR, Inst Biostruct & Bioimaging, Via T De Amicis 95, I-80145 Naples, ItalyCNR, Inst Biostruct & Bioimaging, Via T De Amicis 95, I-80145 Naples, Italy
Gramanzini, Matteo
Mancini, Marcello
论文数: 0引用数: 0
h-index: 0
机构:
CNR, Inst Biostruct & Bioimaging, Via T De Amicis 95, I-80145 Naples, ItalyCNR, Inst Biostruct & Bioimaging, Via T De Amicis 95, I-80145 Naples, Italy
Mancini, Marcello
[J].
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,
2016,
17
(09):
机构:
Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
He, Sitian
He, Leiliang
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
He, Leiliang
Liu, Beibei
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
Liu, Beibei
Yu, Songcheng
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
Yu, Songcheng
Liu, Li'e
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
Liu, Li'e
Tian, Yongmei
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
Tian, Yongmei
Wang, Jia
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
Wang, Jia
Ding, Lihua
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
Ding, Lihua
Wang, Yilin
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
Wang, Yilin
Qu, Lingbo
论文数: 0引用数: 0
h-index: 0
机构:
Henan Joint Int Res Lab Green Construct Funct Mol, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
Qu, Lingbo
Yu, Fei
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
Yu, Fei
Wu, Yongjun
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
机构:
Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia
Univ New South Wales, Sch Med Sci, Fac Med, Sydney, NSW 2052, Australia
Univ Western Sydney, Sch Med, Campbelltown, NSW 2560, AustraliaRussian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia
Bobryshev, Yuri V.
Ivanova, Ekaterina A.
论文数: 0引用数: 0
h-index: 0
机构:
Katholieke Univ Leuven, Dept Dev & Regenerat, B-3000 Leuven, BelgiumRussian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia
Ivanova, Ekaterina A.
Chistiakov, Dimitry A.
论文数: 0引用数: 0
h-index: 0
机构:
Res Ctr Childrens Hlth, Inst Pediat, Dept Mol Genet Diagnost & Cell Biol, Moscow 119991, RussiaRussian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia
Chistiakov, Dimitry A.
Nikiforov, Nikita G.
论文数: 0引用数: 0
h-index: 0
机构:
Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia
Skolkovo Innovat Ctr, Inst Atherosclerosis, Moscow 143025, RussiaRussian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia
Nikiforov, Nikita G.
Orekhov, Alexander N.
论文数: 0引用数: 0
h-index: 0
机构:
Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia
Skolkovo Innovat Ctr, Inst Atherosclerosis, Moscow 143025, Russia
Moscow MV Lomonosov State Univ, Fac Biol, Dept Biophys, Moscow 119991, RussiaRussian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia
机构:
CNR, Inst Biostruct & Bioimaging, Via T De Amicis 95, I-80145 Naples, ItalyCNR, Inst Biostruct & Bioimaging, Via T De Amicis 95, I-80145 Naples, Italy
Gargiulo, Sara
Gramanzini, Matteo
论文数: 0引用数: 0
h-index: 0
机构:
CNR, Inst Biostruct & Bioimaging, Via T De Amicis 95, I-80145 Naples, ItalyCNR, Inst Biostruct & Bioimaging, Via T De Amicis 95, I-80145 Naples, Italy
Gramanzini, Matteo
Mancini, Marcello
论文数: 0引用数: 0
h-index: 0
机构:
CNR, Inst Biostruct & Bioimaging, Via T De Amicis 95, I-80145 Naples, ItalyCNR, Inst Biostruct & Bioimaging, Via T De Amicis 95, I-80145 Naples, Italy
Mancini, Marcello
[J].
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,
2016,
17
(09):
机构:
Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
He, Sitian
He, Leiliang
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
He, Leiliang
Liu, Beibei
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
Liu, Beibei
Yu, Songcheng
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
Yu, Songcheng
Liu, Li'e
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
Liu, Li'e
Tian, Yongmei
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
Tian, Yongmei
Wang, Jia
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
Wang, Jia
Ding, Lihua
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
Ding, Lihua
Wang, Yilin
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
Wang, Yilin
Qu, Lingbo
论文数: 0引用数: 0
h-index: 0
机构:
Henan Joint Int Res Lab Green Construct Funct Mol, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
Qu, Lingbo
Yu, Fei
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
Yu, Fei
Wu, Yongjun
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R ChinaZhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China