Herpesviral protein networks and their interaction with the human proteome

被引：310

作者：

Uetz, P

Dong, YA

Zeretzke, C

Atzler, C

Baiker, A

Berger, B

Rajagopala, SV

Roupelieva, M

Rose, D

Fossum, E

Haas, J

机构：

[1] Univ Munich, Max Von Pettenkofer Inst, D-80336 Munich, Germany

[2] Forschungszentrum Karlsruhe, Inst Genet, D-76021 Karlsruhe, Germany

[3] MIT, Dept Math, Cambridge, MA 02139 USA

来源：

SCIENCE | 2006年 / 311卷 / 5758期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1126/science.1116804

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The comprehensive yeast two-hybrid analysis of intraviral protein interactions in two members of the herpesvirus family, Kaposi sarcoma-associated herpesvirus (KSHV) and varicella-zoster virus (VZV), revealed 123 and 173 interactions, respectively. Viral protein interaction networks resemble single, highly coupled modules, whereas cellular networks are organized in separate functional submodules. Predicted and experimentally verified interactions between KSHV and human proteins were used to connect the viral interactome into a prototypical human interactome and to simulate infection. The analysis of the combined system showed that the viral network adopts cellular network features and that protein networks of herpesviruses and possibly other intracellular pathogens have distinguishing topologies.

引用

页码：239 / 242

页数：4

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