Role of Thymic Reconstitution in the Outcome of AIDS-Related PML

被引：0

作者：

Chalkias, Spyridon G. ^{[1
,2
,3
,4
]}

Gheuens, Sarah ^{[1
,5
]}

Bord, Evelyn ^{[1
,2
,4
]}

Batson, Stephanie ^{[1
,2
,4
]}

Koralnik, Igor J. ^{[1
,2
,4
]}

机构：

[1] Harvard Univ, Sch Med, Dept Neurol, Div Neuro Immunol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Med, Ctr Virol & Vaccine Res, Boston, MA USA

[3] Harvard Univ, Sch Med, Div Infect Dis, Boston, MA USA

[4] Harvard Univ, Sch Med, Dept Med, Beth Israel Deaconess Med Ctr, Boston, MA USA

[5] Biogen Idec Inc, Cambridge, MA USA

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2015年 / 70卷 / 04期

基金：

美国国家卫生研究院;

关键词：

HIV; thymus; JC virus; progressive multifocal leukoencephalopathy; HIV-INFECTED PATIENTS; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; T-CELL HOMEOSTASIS; RECEIVING ANTIRETROVIRAL THERAPY; JC VIRUS; IMMUNE RECONSTITUTION; LONGITUDINAL ASSESSMENT; OUTPUT; CD4(+); INTERLEUKIN-7;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Implications of thymopoiesis in AIDS-related opportunistic infections remain unexplored. We used progressive multifocal leukoencephalopathy (PML), caused by JC virus (JCV), as an opportunistic infection model, and we simultaneously investigated thymic output and T-cell responses against JCV in 22 patients with PML treated with combined antiretroviral therapy. Thymic output was significantly associated with JCV-specific CD4(+) and CD8(+) T-cell responses and improved survival. Our data suggest that patients with AIDS-related PML and impaired thymopoiesis are less likely to develop a robust JCV-specific cellular immune response and consequently are at an increased risk for a poor clinical outcome.

引用

页码：357 / 361

页数：5

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